4933422H20Rik Inhibitors
The chemical class TRIM80 Inhibitors refers to a diverse group of compounds that indirectly influence the function of TRIM80 by targeting the ubiquitin-proteasome system (UPS) and related cellular processes. These inhibitors typically function by impeding the proteasome's ability to degrade ubiquitinated proteins, leading to an accumulation of these proteins within the cell. This accumulation can have various downstream effects on cellular processes, including those where TRIM80 is presumed to be active.
The compounds in this class include proteasome inhibitors like MG132, Bortezomib, Lactacystin, Withaferin A, Celastrol, Epoxomicin, Velcade, Carfilzomib, Oprozomib, and MLN2238, each of which binds to and inhibits the proteolytic activity of the proteasome. This inhibition can subsequently impact any regulatory roles that TRIM80 has in protein turnover or degradation. Additionally, compounds like Nelfinavir and Disulfiram, although initially developed for other purposes, have been found to have off-target effects on the proteasome, thereby potentially modulating the functional landscape in which TRIM80 operates. By affecting the UPS, these inhibitors can indirectly influence the ubiquitination and subsequent proteasomal degradation of proteins, which is a critical pathway in cellular homeostasis and one in which TRIM80 may have a role.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of ubiquitinated proteins, possibly affecting the turnover of proteins regulated by TRIM80. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Another proteasome inhibitor that can lead to an accumulation of ubiquitinated proteins, which may interfere with TRIM80's putative role in protein degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
A specific inhibitor of the proteasome that can disrupt the degradation of proteins, potentially impacting the functional pathways that TRIM80 is involved in. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that can impair the proteasomal activity, which may influence the ubiquitination processes that TRIM80 could be a part of. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
A quinone methide triterpene that disrupts proteasome activity, which can affect protein turnover and thus potentially impact TRIM80 function. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor that can affect the pathway of protein degradation where TRIM80 may function. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
An epoxyketone proteasome inhibitor that can affect the ubiquitin-proteasome system, potentially altering TRIM80's activity. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
An oral proteasome inhibitor that can disrupt protein degradation pathways, which may influence the functional context of TRIM80. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
A proteasome inhibitor that can lead to the buildup of ubiquitinated substrates, which could affect the functional activity of TRIM80. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
An HIV-protease inhibitor that has been shown to also inhibit the proteasome, which could impact the protein regulatory functions where TRIM80 is implicated. | ||||||