4930534B04Rik Inhibitors
The chemical class referred to as Cep128 Inhibitors consists of compounds with the capability to indirectly influence the function of the centrosomal protein Cep128. These chemicals are not direct antagonists of Cep128 but operate by modulating cellular mechanisms and structures that are crucial for the proper functioning of Cep128 within the cell. Nocodazole and Paclitaxel, for example, exert their effects on microtubule dynamics, a key component of the centrosome and mitotic spindle, to which Cep128 is fundamentally related. Disruption of microtubule dynamics by these agents can lead to a cascading effect that interferes with Cep128's role in spindle assembly and function.
Further to this, inhibitors like Roscovitine and Purvalanol A target CDKs, which are pivotal in cell cycle regulation, including centrosome duplication and maturation, processes that are likely to involve Cep128. Similarly, compounds such as BI 2536 and Centrinone interfere with proteins like Plk1 and PLK4, respectively, which are essential for centrosome and spindle function, thereby indirectly affecting the role of Cep128. Aurora kinase inhibitors such as ZM447439 and AZD1152-HQPA are included in this class because they disrupt chromosome alignment and segregation during mitosis, processes that are potentially mediated by Cep128.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule-depolymerizing agent that can disrupt microtubule dynamics, affecting centrosome function and possibly Cep128's role in spindle assembly. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule-stabilizing drug that can alter microtubule dynamics and potentially influence Cep128 activity related to spindle formation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
An inhibitor of cyclin-dependent kinases (CDKs) that can disrupt cell cycle progression and centrosome duplication, potentially affecting Cep128 functions. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
A kinesin Eg5 inhibitor that can impair spindle pole separation, potentially influencing Cep128's role in spindle assembly. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Another CDK inhibitor that can interfere with cell cycle regulation and indirectly affect Cep128's centrosomal functions. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
A Plk1 inhibitor that can disrupt centrosome maturation and spindle assembly, potentially impacting Cep128 activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor that can disrupt chromosome alignment and segregation, possibly affecting Cep128's role in these processes. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
A kinesin Eg5 inhibitor that can disrupt mitotic spindle dynamics, potentially influencing Cep128's function. | ||||||
AZD1152-HQPA | 722544-51-6 | sc-265334 | 10 mg | $375.00 | ||
A selective inhibitor of Aurora B kinase that can affect cytokinesis and chromosome segregation, which may impact Cep128 activities. | ||||||
MLN 8054 | 869363-13-3 | sc-484828 | 5 mg | $398.00 | ||
An Aurora A kinase inhibitor that can impair mitotic entry and spindle assembly, potentially impacting Cep128 activity. | ||||||