4930468A15Rik Inhibitors

Cldn34d Inhibitors refers to a diverse group of chemicals that can indirectly affect the function of the protein claudin 34D (CLDN34D). These compounds interact with various cellular pathways and structures that are associated with the regulation and maintenance of tight junctions, of which CLDN34D is an integral component. The integrity and function of tight junctions are critical for their role in controlling paracellular transport and maintaining cell polarity.

Chemicals such as CPE and WGA can directly bind to claudins, potentially altering the function of CLDN34D within tight junctions. Compounds that affect the redox state of cells, such as DTT, or the glycosylation status, such as tunicamycin, can modify the structure and function of membrane proteins including CLDN34D. Calcium chelators like EGTA can disrupt calcium-dependent interactions that are necessary for tight junction stability, thereby potentially affecting CLDN34D's role in these structures. Inhibitors of signaling molecules and pathways, such as Y-27632, forskolin, calyculin A, chelerythrine, gefitinib, and staurosporine, can lead to changes in tight junction assembly, disassembly, or function, thereby indirectly influencing the role of CLDN34D. Amiloride's action on transcellular transport can lead to changes in the cellular ionic environment, which can have a downstream effect on tight junction dynamics and the functioning of CLDN34D.