4.1R Activators
4.1R Activators are chemical compounds that specifically influence signaling events leading to the direct or indirect activation of 4.1R. These compounds work by targeting various cellular structures and pathways that 4.1R is involved in. For instance, Latrunculin A and Cytochalasin D disrupt actin cytoskeleton, indirectly enhancing the functional activity of 4.1R, which is a cytoskeletal protein associated with actin-based structures. Similarly, Jasplakinolide induces actin polymerization, indirectly leading to the activation of 4.1R, which is known to bind to actin filaments and stabilize them. Other compounds such as Y-27632 inhibit ROCK, a kinase involved in actin cytoskeleton formation. By inhibiting ROCK, they can enhance the functional activity of 4.1R, which stabilizes actin structures. Phalloidin, a molecule that binds to actin filamentsand stabilizes them, can also enhance the functional activity of 4.1R. EHNA, an adenosine deaminase inhibitor, can increase the activity of protein kinase A, enhancing the phosphorylation and activation of 4.1R. Similarly, Forskolin activates adenylate cyclase, increasing the levels of cAMP leading to increased protein kinase A activity and enhanced phosphorylation and activation of 4.1R.
Compounds such as Okadaic acid, Calyculin A, and Pervanadate are potent inhibitors of protein phosphatases. Inhibition of these phosphatases increases the phosphorylation state of various proteins, including 4.1R, thus enhancing its functional activity. Nocodazole disrupts microtubules leading to reorganization of the actin cytoskeleton, which can enhance the functional activity of 4.1R due to its role in actin-based structures. Lastly, Neomycin disrupts lipid rafts in the plasma membrane, leading to alterations in the actin cytoskeleton and thus enhancing the functional activity of 4.1R. These compounds work in concert to influence the activity of 4.1R through various specific biochemical and cellular pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization. This action disrupts actin cytoskeleton, and as such, indirectly enhances the functional activity of 4.1R, which is a cytoskeletal protein associated with actin-based structures. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an actin polymerization inducer, enhancing the formation of the actin cytoskeleton. Indirectly, this can lead to the activation of 4.1R, which is known to bind to actin filaments and stabilize them. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of ROCK. ROCK is involved in actin cytoskeleton formation, and inhibiting it can enhance the functional activity of 4.1R, which stabilizes actin structures. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin is a molecule that binds to actin filaments and stabilizes them. This action can enhance the functional activity of 4.1R, which is known to bind to actin filaments. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules. This disruption can lead to the reorganization of the actin cytoskeleton, which can enhance the functional activity of 4.1R due to its role in actin-based structures. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can increase the phosphorylation state of various proteins, including 4.1R, thereby enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing the levels of cAMP. This can lead to increased protein kinase A activity, which can enhance the phosphorylation and activation of 4.1R. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Pervanadate is a potent inhibitor of protein tyrosine phosphatases. Inhibition of these phosphatases can increase the phosphorylation state of various proteins, including 4.1R, thereby enhancing its functional activity. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin is a compound known to disrupt lipid rafts in the plasma membrane. This disruption can lead to alterations in the actin cytoskeleton, which can enhance the functional activity of 4.1R due to its role in actin-based structures. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can increase the phosphorylation state of various proteins, including 4.1R, thereby enhancing its functional activity. | ||||||