3110007F17Rik Activators
Chemical activators of claudin 34C1 encompass a range of compounds that initiate various intracellular signaling cascades, culminating in the phosphorylation and subsequent activation of this tight junction protein. Forskolin, by increasing intracellular cyclic AMP (cAMP) levels, indirectly stimulates protein kinase A (PKA), which then phosphorylates claudin 34C1, potentially enhancing its function in maintaining tight junction integrity. Similarly, dibutyryl-cAMP (db-cAMP), a cAMP analog, directly activates PKA leading to phosphorylation events that activate claudin 34C1. Phorbol 12-myristate 13-acetate (PMA) and 1,2-Dioctanoyl-sn-glycerol (DiC8), a synthetic analog of diacylglycerol, both serve as activators of protein kinase C (PKC). Upon activation, PKC phosphorylates claudin 34C1, which is thought to influence the protein's role in tight junction assembly and barrier function.
Further activation mechanisms involve growth factors and other signaling molecules. Epidermal Growth Factor (EGF) activates its receptor, triggering the MAPK/ERK pathway, which is known to participate in the regulation of various proteins, including claudin 34C1. Hepatocyte Growth Factor (HGF) interacts with the c-Met receptor and engages the PI3K-Akt pathway, which has implications for claudin 34C1 activity in cell junction assembly. FTY720, after being phosphorylated in vivo, mimics sphingosine 1-phosphate and activates S1P receptors, influencing cellular dynamics that can affect the function of claudin 34C1. Anandamide, through cannabinoid receptors, activates kinases including PKA and PKC, which may lead to the phosphorylation and activation of claudin 34C1. Genistein, despite being a tyrosine kinase inhibitor, can activate signaling pathways by inhibiting regulatory kinases, thereby potentially promoting the activation of claudin 34C1. Finally, the calcium ionophore A23187 elevates intracellular calcium levels, which activates calcium-sensitive signaling proteins, and Benzimidazole activates cellular kinases, both of which can result in the phosphorylation and activation of claudin 34C1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA directly activates protein kinase C (PKC), which can phosphorylate and thus activate claudin 34C1 as part of the regulation of tight junction dynamics. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic diacylglycerol analog that activates PKC. The activated PKC can phosphorylate claudin 34C1, potentially enhancing its tight junction assembly and barrier function. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is phosphorylated in vivo to form FTY720-phosphate, which can mimic sphingosine 1-phosphate (S1P). This agonist can activate S1P receptors, leading to downstream effects that may include the activation of claudin 34C1 through cytoskeletal rearrangements. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that, paradoxically, can activate certain signaling pathways by blocking negative regulatory kinases, potentially leading to the activation of claudin 34C1 through phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. This activation can result in the phosphorylation and activation of claudin 34C1, thereby affecting tight junction integrity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium levels, which can activate calcium-sensitive signaling molecules, potentially leading to the activation of claudin 34C1 through calcium-dependent phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, but through feedback loops, it can lead to the activation of compensatory pathways that may result in the activation of claudin 34C1, as part of cellular junctional responses. | ||||||