3β-HSD Activators
The chemical class of 3β-HSD Activators refers to a group of compounds that specifically interact with and activate the enzyme 3β-Hydroxysteroid Dehydrogenase (3β-HSD). This enzyme plays a crucial role in the biosynthesis of all classes of steroid hormones, including glucocorticoids, mineralocorticoids, androgens, and estrogens. The activation of 3β-HSD by these compounds leads to an increase in the production of these steroid hormones. The 3β-HSD enzyme is present in various tissues, such as the adrenal glands, gonads, and placenta, and is involved in the conversion of pregnenolone to progesterone, a key step in steroidogenesis.
The structure of 3β-HSD activators is diverse, reflecting the varied approaches to designing molecules that can effectively interact with the enzyme's active site. These activators are generally characterized by their ability to bind to the enzyme and enhance its catalytic activity. This enhancement can be achieved through a variety of mechanisms, such as stabilizing the enzyme in an active conformation, increasing the enzyme's affinity for its substrates, or facilitating the release of products. The design of these molecules often involves careful consideration of the enzyme's structure and the dynamic nature of its active site. Research in this field focuses on understanding the precise interactions between these activators and the enzyme, which can involve a range of techniques from computational modeling to experimental biochemistry. This understanding is crucial for the development of more effective and selective activators of 3β-HSD.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA directly enhances the substrate availability for 3β-HSD, thereby increasing its enzymatic activity in the biosynthesis of androgens and estrogens. By supplying more substrate, DHEA ensures that 3β-HSD is more actively engaged in the conversion process, leading to an upsurge in the production of downstream hormones. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a cofactor, NAD+, Free Acid is essential for the enzymatic activity of 3β-HSD, which involves the oxidation and reduction of steroids. Increased availability of NAD+, Free Acid can enhance the enzyme's activity. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone acts as a direct substrate for 3β-HSD, facilitating its enzymatic action in steroidogenesis. This activation promotes the conversion of pregnenolone to progesterone, showcasing a direct influence on the activation and functionality of 3β-HSD in the steroid biosynthesis pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate and activate 3β-HSD indirectly. This activation enhances the enzyme's catalytic efficiency in steroidogenesis. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
As a coenzyme of many enzymatic reactions, Pyridoxal phosphate indirectly supports 3β-HSD activity by stabilizing enzyme-substrate complexes. This stabilization can enhance the enzymatic conversion efficiency, thus indirectly activating 3β-HSD in its role in steroid metabolism. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium acts as a cofactor for numerous enzymes, including those in the steroidogenesis pathway. By stabilizing 3β-HSD structure and enhancing substrate affinity, magnesium sulfate indirectly activates 3β-HSD, improving its functionality in hormone synthesis. | ||||||
Zinc sulfate solution | 7733-02-0 | sc-251451 | 250 ml | $110.00 | ||
Zinc is crucial for the structural integrity of many enzymes, including 3β-HSD. By binding to the enzyme, zinc sulfate can improve its catalytic activity, indirectly activating 3β-HSD and promoting efficient steroid biosynthesis. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is involved in nitric oxide synthesis, which can indirectly affect steroidogenesis. Through its role in signaling pathways, L-Arginine might enhance the activity of 3β-HSD indirectly by modulating cellular environments conducive to its activation. | ||||||
L-Citrulline | 372-75-8 | sc-204784 sc-204784A | 5 g 200 g | $31.00 $235.00 | ||
L-Citrulline is converted to L-Arginine in the body, which can enhance the production of nitric oxide. This process indirectly supports the activation of 3β-HSD by improving the cellular conditions necessary for its enzymatic activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences various signaling pathways, including those involved in steroidogenesis. Its action can lead to an indirect activation of 3β-HSD by modifying the intracellular environment and enhancing enzyme efficiency in hormone production. | ||||||