2610039C10Rik Inhibitors
The chemical class referred to as Mis18a Inhibitors consists of a series of compounds that can indirectly affect the function of Mis18a by targeting cellular processes and signaling pathways related to kinetochore assembly, microtubule dynamics, and cell cycle regulation. These compounds are diverse and include microtubule stabilizers or destabilizers such as Paclitaxel and Nocodazole, which can impede the proper attachment of kinetochores to microtubules and therefore may influence Mis18a's function in chromosome segregation.
Other compounds in this class target key proteins involved in cell cycle progression and spindle assembly. For instance, Purvalanol A and Roscovitine are cyclin-dependent kinase inhibitors that can arrest cell cycle progression, thereby indirectly affecting the recruitment of Mis18a to the centromere. Similarly, inhibitors like BI 2536 and Alisertib target Polo-like kinase 1 and Aurora A kinase, respectively, both of which are critical for the proper functioning of the spindle and can thereby influence Mis18a's role in the centromere. Inhibition of these kinases can result in impaired spindle assembly and function, potentially affecting the Mis18a-dependent centromere recruitment process.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and can disrupt kinetochore-microtubule attachment, which may affect Mis18a's function in chromosome segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Destabilizes microtubules, potentially disrupting kinetochore function and indirectly affecting Mis18a's role. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule depolymerizing agent that can disrupt kinetochore fibers, possibly affecting Mis18a-related processes. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits kinesin Eg5, leading to monopolar spindle formation, which can indirectly affect Mis18a's function at the kinetochore. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin and prevents microtubule polymerization, potentially disrupting kinetochore function and Mis18a's role. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
A cyclin-dependent kinase inhibitor that can affect cell cycle progression, indirectly influencing Mis18a's role in chromosome segregation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Another cyclin-dependent kinase inhibitor that can alter cell cycle progression and potentially affect Mis18a function. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Inhibits Polo-like kinase 1 (Plk1), which can impair spindle assembly and indirectly affect Mis18a's role at the kinetochore. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Inhibits Aurora kinases, which are involved in kinetochore-microtubule attachment, possibly impacting Mis18a's function. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
A specific inhibitor of kinesin Eg5, which can cause defects in spindle formation, potentially affecting Mis18a's role. | ||||||