2310004I24Rik Inhibitors
Chemical inhibitors of 2310004I24Rik can modulate its activity through various mechanisms by targeting the kinases that regulate its function. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit the phosphorylation of 2310004I24Rik by a wide range of kinases, thus affecting its activity. Similarly, Bisindolylmaleimide I, a specific inhibitor of Protein Kinase C (PKC), can prevent the activation of 2310004I24Rik if it is regulated by PKC-mediated phosphorylation. LY294002, which targets PI3K, can reduce the activity of 2310004I24Rik if it operates downstream of the PI3K signaling cascade. Rapamycin, an mTOR inhibitor, can indirectly inhibit 2310004I24Rik if it is associated with mTOR signaling pathways, which are crucial for cell growth and proliferation.
Furthermore, PD98059 and U0126, both selective inhibitors of MEK1/2, can prevent the activation of ERK and consequently inhibit the activity of 2310004I24Rik if it lies downstream in the MAPK/ERK pathway. SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, can also decrease 2310004I24Rik activity by targeting these specific MAPK pathways. Src family kinases, which can regulate 2310004I24Rik, are targeted by PP2 and Dasatinib; the inhibition of these kinases can lead to a reduction in 2310004I24Rik activity. Lastly, Erlotinib and Sorafenib, which inhibit EGFR tyrosine kinase and RAF kinases respectively, can decrease the activity of 2310004I24Rik by interfering with their respective signaling pathways, which may involve this protein. Each of these inhibitors can thus affect the functional state of 2310004I24Rik by disrupting the activity of upstream kinases responsible for its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad spectrum of protein kinases. As 2310004I24Rik's function is dependent on phosphorylation by specific kinases, staurosporine can inhibit these kinases, thereby inhibiting the phosphorylation and subsequent activity of 2310004I24Rik. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of Protein Kinase C (PKC). If 2310004I24Rik is regulated by PKC-mediated signaling, this compound would inhibit that signaling, thus inhibiting 2310004I24Rik's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K. If 2310004I24Rik operates downstream of PI3K, this chemical would inhibit the PI3K pathway, leading to inhibition of 2310004I24Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation. Inhibition of mTOR can indirectly lead to the functional inhibition of 2310004I24Rik if it is involved in mTOR signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. Inhibition of MEK would prevent activation of ERK and potentially inhibit downstream proteins like 2310004I24Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 also selectively inhibits MEK1/2 in the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 would indirectly inhibit the functional activity of 2310004I24Rik if it is part of the MAPK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. By inhibiting p38 MAPK, SB203580 would prevent activation of downstream targets, potentially including 2310004I24Rik if it is within this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which could lead to inhibition of 2310004I24Rik if it functions downstream or is regulated by JNK activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. If 2310004I24Rik is activated by Src family kinases, PP2 would inhibit this activation, leading to inhibition of 2310004I24Rik. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a multi-targeted kinase inhibitor, including Src family kinases. It would inhibit 2310004I24Rik by inhibiting kinases that activate or regulate it. | ||||||