2010012O05Rik Activators
Chemical activators of BLOC-1 related complex subunit 7 can engage various signaling pathways to facilitate its activation. Bisindolylmaleimide and Phorbol 12-myristate 13-acetate (PMA) are known to activate Protein Kinase C (PKC), which plays a pivotal role in signaling pathways that lead to the activation of BLOC-1 related complex subunit 7. PKC can increase the phosphorylation levels of proteins within the BLOC-1 pathway, thereby promoting the assembly or enhancing the interaction of BLOC-1 related complex subunit 7 with other members of the BLOC-1 complex. Forskolin operates through a different mechanism, activating adenylate cyclase to increase cyclic AMP levels, which in turn activate Protein Kinase A (PKA). PKA then phosphorylates target proteins that can interact with and activate BLOC-1 related complex subunit 7, further influencing its functional state.
Additionally, Ionomycin raises intracellular calcium levels, leading to the activation of calcineurin, a phosphatase that can dephosphorylate certain substrates, thereby allowing for the activation of BLOC-1 related complex subunit 7. Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, leading to a general increase in phosphorylation within the cell, which includes proteins that are part of the BLOC-1 pathway. Anisomycin activates stress-activated protein kinases, which can directly phosphorylate and activate BLOC-1 related complex subunit 7. Thapsigargin and A23187 (Calcimycin) disturb calcium homeostasis, which is a crucial secondary messenger in various signaling pathways, and its increase can activate proteins that modulate the activity of BLOC-1 related complex subunit 7. Staurosporine, although generally an inhibitor of kinases, can at low concentrations activate several kinases, which can then phosphorylate proteins within the BLOC-1 pathway, influencing the activation state of BLOC-1 related complex subunit 7. Lastly, signaling molecules like Retinoic Acid and Epidermal Growth Factor (EGF) can modulate cellular processes by upregulating kinases or other modifying enzymes, potentially having a direct influence on the activation of BLOC-1 related complex subunit 7.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide activates protein kinase C (PKC), which is involved in signaling pathways that lead to the activation of BLOC-1 related complex subunit 7 by promoting its assembly or enhancing its interaction with other BLOC-1 complex members. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates PKC, potentially increasing the phosphorylation levels of proteins within the BLOC-1 pathway, thereby facilitating the functional activation of BLOC-1 related complex subunit 7. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, indirectly activating calcineurin. Active calcineurin can dephosphorylate proteins that may enhance the activation of BLOC-1 related complex subunit 7. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatase PP1 and PP2A, leading to increased phosphorylation within the cell. This may result in the activation of BLOC-1 related complex subunit 7 through enhanced phosphorylation signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits PP1 and PP2A phosphatases, causing hyperphosphorylation in cells, which can lead to the activation of proteins associated with the BLOC-1 pathway, including BLOC-1 related complex subunit 7. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs/JNKs), which can phosphorylate and thereby activate components of the BLOC-1 pathway including BLOC-1 related complex subunit 7. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor which leads to increased cytosolic calcium, potentially activating downstream calcium-sensitive proteins that might interact with and activate BLOC-1 related complex subunit 7. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor, but at low concentrations, it paradoxically acts as an activator for several kinases which could phosphorylate proteins within the BLOC-1 pathway, leading to activation of BLOC-1 related complex subunit 7. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, which may indirectly activate signaling cascades involving calcium-binding proteins that activate BLOC-1 related complex subunit 7. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can modulate cellular differentiation and proliferation pathways, which may include the upregulation of kinases or other modifying enzymes that could directly activate BLOC-1 related complex subunit 7. | ||||||