1700018P22Rik Inhibitors
Chemical inhibitors of 1700018P22Rik can interfere with its function through various mechanisms by targeting different signaling pathways and kinases. Staurosporine, a potent kinase inhibitor, can inhibit a broad spectrum of kinases involved in phosphorylation, which is a crucial regulatory process for proteins, including 1700018P22Rik. This inhibition can prevent essential phosphorylation events required for 1700018P22Rik's function. Similarly, Bisindolylmaleimide I, by specifically inhibiting Protein Kinase C (PKC), can disrupt the phosphorylation process if PKC-mediated phosphorylation is necessary for 1700018P22Rik's activity. LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3K) inhibitors, can block the PI3K/Akt pathway. If 1700018P22Rik is a part of this pathway, its activity would be inhibited due to the prevention of downstream signaling.
Furthermore, Rapamycin targets the mTOR signaling pathway, which is integral to cell growth and proliferation. Inhibition of mTOR can lead to reduced activity of 1700018P22Rik if it is linked to this pathway. U0126 and PD98059 are inhibitors of MEK1/2 and by inhibiting this kinase, they can decrease the activity of the ERK pathway, which, in turn, can inhibit 1700018P22Rik if it is a downstream effector. SB203580's inhibition of p38 MAP kinase can affect 1700018P22Rik if it is involved in stress response pathways reliant on p38 MAPK. Similarly, SP600125's inhibition of JNK can decrease 1700018P22Rik activity if JNK signaling regulates it. Lastly, Dasatinib and PP2, as Src family kinase inhibitors, can inhibit Src kinase signaling, leading to reduced 1700018P22Rik activity if Src kinases regulate it. ZM-447439's role as an Aurora kinase inhibitor can also affect 1700018P22Rik's function if it is involved in the cell cycle and dependent on Aurora kinase activity for its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad range of protein kinases, which may include kinases necessary for the activation or function of 1700018P22Rik. By inhibiting these kinases, Staurosporine prevents the phosphorylation that 1700018P22Rik requires for its activity, leading to its functional inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
As a specific inhibitor of Protein Kinase C (PKC), Bisindolylmaleimide I could inhibit 1700018P22Rik's function if the protein's activity is regulated by PKC-mediated phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that would inhibit 1700018P22Rik by blocking the PI3K/Akt pathway, which is crucial for several cellular functions. If 1700018P22Rik is involved in this pathway, its activity would be inhibited as a result of the blockade. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin functions as an inhibitor of PI3K. If 1700018P22Rik operates within the PI3K/Akt signaling pathway, Wortmannin's inhibitory effect on PI3K would lead to a decrease in 1700018P22Rik activity by preventing signal transduction. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation. If 1700018P22Rik's function is tied to the mTOR signaling pathway, then inhibition by Rapamycin would result in a decrease in 1700018P22Rik's activity due to disrupted mTOR signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 specifically inhibits MEK, which if 1700018P22Rik is reliant on the MEK/ERK pathway for its function, would result in inhibition of the protein's activity through blocking of this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. By inhibiting p38 MAPK, this compound would lead to functional inhibition of 1700018P22Rik if it is involved in cellular stress response pathways that require p38 MAPK activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, and if 1700018P22Rik's function is regulated by JNK signaling, this inhibition would result in a direct decrease of 1700018P22Rik activity due to disrupted signal transduction. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib serves as a Src family kinase inhibitor. If 1700018P22Rik is activated or regulated by Src kinase signaling, then inhibition by Dasatinib would lead to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is another Src family kinase inhibitor. The inhibition of Src kinases by PP2 would lead to functional inhibition of 1700018P22Rik if Src kinase activity is necessary for the proper function of the protein. | ||||||