1700018A14Rik Inhibitors
hemical inhibitors of protein 1700018A14Rik operate through various mechanisms to modulate its function by targeting specific signaling pathways and kinases. Staurosporine, a potent kinase inhibitor, can inhibit the activity of a broad range of protein kinases that may interact with or regulate 1700018A14Rik, leading to its functional inhibition. Similarly, Bisindolylmaleimide I, which selectively inhibits Protein Kinase C (PKC), can prevent the phosphorylation of 1700018A14Rik if it is a substrate of PKC, thereby inhibiting its function. LY294002 and Wortmannin both act as PI3K inhibitors, potentially disrupting the PI3K/AKT signaling pathway that 1700018A14Rik may be part of, resulting in its functional inhibition. The effectiveness of these inhibitors in impeding the function of 1700018A14Rik underscores the protein's potential involvement in critical kinase-regulated pathways.
Continuing with the theme of targeted inhibition, Rapamycin can inhibit the function of 1700018A14Rik through the inhibition of mTOR, a key regulator of cell growth and proliferation that 1700018A14Rik may be associated with. U0126 and PD98059, both MEK inhibitors, can prevent the activation of ERK, a downstream effect that would functionally inhibit 1700018A14Rik if it is regulated by the MEK/ERK pathway. SB203580, which selectively inhibits p38 MAP kinase, and SP600125, a JNK inhibitor, can both impede the function of 1700018A14Rik if it is involved in the p38 MAPK or JNK stress response pathways, respectively. Dasatinib and PP2, as Src family kinase inhibitors, can inhibit 1700018A14Rik if it is activated by Src family kinases. Lastly, ZM-447439 targets Aurora kinase, and if 1700018A14Rik is involved in cell cycle regulation dependent on Aurora kinase activity, this inhibitor can lead to its functional inhibition. Each inhibitor's specific interaction with 1700018A14Rik provides insight into the protein's role within these signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad range of protein kinases, and if 1700018A14Rik is regulated by or interacts with any of these kinases, staurosporine can inhibit these interactions, leading to functional inhibition of 1700018A14Rik. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I selectively inhibits Protein Kinase C (PKC), potentially leading to the functional inhibition of 1700018A14Rik if it is a substrate or is regulated by PKC-mediated phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and by inhibiting PI3K, it can disrupt downstream AKT signaling. If 1700018A14Rik functions downstream of AKT or is regulated by AKT-mediated pathways, LY294002 can lead to the functional inhibition of 1700018A14Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, and it can inhibit the PI3K/AKT pathway. If 1700018A14Rik is part of this pathway or is regulated by it, the inhibition of PI3K can result in the functional inhibition of 1700018A14Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and proliferation. If 1700018A14Rik is involved in mTOR signaling or is regulated by mTOR, Rapamycin can inhibit the function of 1700018A14Rik by inhibiting mTOR activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream regulators of the ERK signaling pathway. Inhibition of MEK1/2 by U0126 can lead to the functional inhibition of 1700018A14Rik if it is regulated by the MEK/ERK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of ERK. If 1700018A14Rik is regulated by ERK signaling, PD98059 can functionally inhibit 1700018A14Rik through the inhibition of MEK, thereby preventing ERK activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase. If 1700018A14Rik is a downstream effector of the p38 MAP kinase pathway or relies on p38 MAPK for its function, SB203580 can functionally inhibit 1700018A14Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, modulating stress response pathways. If 1700018A14Rik functions as part of the JNK signaling pathway or is regulated by it, SP600125 can functionally inhibit 1700018A14Rik by inhibiting JNK activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. If 1700018A14Rik is activated by or interacts with Src family kinases, Dasatinib can functionally inhibit 1700018A14Rik by inhibiting Src family kinases. | ||||||