1700011L22Rik Inhibitors
Chemical inhibitors of the protein 1700011L22Rik function by disrupting various signaling pathways within the cell, leading to a decrease in its activity. Wortmannin and LY294002 are specific inhibitors of phosphoinositide 3-kinases (PI3K), a family of enzymes involved in cellular functions such as growth, proliferation, differentiation, motility, and survival. By inhibiting PI3K, these chemicals prevent the activation of AKT, a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes. The inhibition of AKT by Wortmannin and LY294002, as well as by Triciribine, a direct AKT inhibitor, results in a reduced phosphorylation of downstream targets, which includes the functional inhibition of 1700011L22Rik. ZSTK474, another PI3K inhibitor, similarly disrupts the PI3K/AKT signaling pathway, attenuating the activity of 1700011L22Rik.
Parallel to PI3K/AKT pathway inhibitors, the chemical rapamycin specifically inhibits mTOR (mammalian target of rapamycin), which is also involved in the PI3K/AKT/mTOR pathway. The mTOR signaling pathway plays a crucial role in cellular growth and metabolism, and its inhibition by rapamycin, as well as by PP242, a selective mTOR kinase inhibitor, and Torin 1, which targets both mTORC1 and mTORC2 complexes, leads to a decrease in activity of proteins regulated by this pathway, including 1700011L22Rik. Inhibition of other signaling pathways that can affect the function of 1700011L22Rik includes the use of PD98059 and U0126, which are selective inhibitors of MEK1/2 and therefore prevent the activation of ERK1/2 in the MAPK/ERK pathway. SB203580, which specifically inhibits p38 MAP kinase, and SP600125, an inhibitor of JNK, both from the MAPK family, also contribute to the inhibition of 1700011L22Rik by interfering with stress response pathways and other MAPK-regulated processes. PF-04691502 rounds out the list of inhibitors by simultaneously targeting both PI3K and mTOR, leading to a broad inhibition of the signaling required for the proper function of 1700011L22Rik.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. PI3K signaling is crucial for many cellular processes, and by inhibiting this kinase, Wortmannin can reduce the phosphorylation of downstream targets that may include 1700011L22Rik, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another specific inhibitor of PI3K. By blocking PI3K activity, LY294002 prevents the activation of AKT, a kinase downstream of PI3K, which is essential for full activation of multiple proteins, including possibly 1700011L22Rik, thus inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTOR (mammalian target of rapamycin), which is part of the PI3K/AKT/mTOR pathway. Inhibition of mTOR can lead to reduced activity of proteins regulated by this pathway, which may include the functional inhibition of 1700011L22Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2, which are upstream of ERK1/2 in the MAPK/ERK pathway. By inhibiting MEK, PD98059 prevents the activation of ERK, which in turn could lead to the functional inhibition of target proteins such as 1700011L22Rik that are regulated by this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a non-competitive inhibitor of MEK1/2, similar to PD98059. It inhibits the MAPK/ERK pathway, leading to decreased ERK phosphorylation and activity. This reduction in ERK activity can inhibit the function of proteins like 1700011L22Rik that may be downstream in this signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. The p38 MAP kinase pathway is implicated in stress responses, and inhibition of p38 MAPK by SB203580 can inhibit the function of downstream proteins such as 1700011L22Rik, which may be regulated by this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), part of the MAPK family. Inhibition of JNK by SP600125 can decrease the activity of transcription factors and other proteins that are regulated by the JNK signaling pathway, potentially including 1700011L22Rik. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a potent inhibitor of both mTORC1 and mTORC2 complexes. By inhibiting these complexes, Torin 1 can suppress the mTOR signaling pathway, leading to functional inhibition of proteins that are regulated by mTOR, potentially including 1700011L22Rik. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of mTOR kinase, targeting both mTORC1 and mTORC2. It inhibits the kinase activity of mTOR, which can lead to the functional inhibition of downstream proteins that are dependent on mTOR signaling, such as 1700011L22Rik. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an inhibitor of AKT. It prevents the phosphorylation and activation of AKT, thereby inhibiting the downstream signaling pathways that rely on AKT activity, including those that could be regulating the function of 1700011L22Rik. | ||||||