1700011F14Rik Activators
Coiled-coil domain-containing protein 172 activators are a diverse set of compounds that facilitate the enhancement of the protein's activity through various intracellular pathways. Forskolin, for instance, by raising cAMP levels, activates PKA, which may phosphorylate substrates that directly enhance the activity of Coiled-coil domain-containing protein 172. Similarly, Genistein, by inhibiting tyrosine kinases, potentially grants Coiled-coil domain-containing protein 172 a more active role in its signaling pathways by reducing competitive phosphorylation. Sphingosine-1-phosphate and Thapsigargin, by modulating lipid signaling and increasing intracellular calcium respectively, create a cellular environment. Coiled-coil domain-containing protein 172 activators are a curated selection of chemical compounds that promote the protein's functional activity through precise cellular signaling mechanisms. Forskolin, by increasing intracellular levels of cAMP, indirectly fosters the activity of Coiled-coil domain-containing protein 172 by activating Protein Kinase A, which can phosphorylate specific substrates that interact with or regulate the protein.
Further, Sphingosine-1-phosphate, through receptor-mediated signaling, and Thapsigargin, by elevating cytosolic calcium, each contribute to the protein's activation by influencing secondary messengers and downstream signaling cascades that Coiled-coil domain-containing protein 172 is part of. Phorbol 12-myristate 13-acetate (PMA), as a PKC activator, and Epigallocatechin gallate (EGCG), as a kinase inhibitor, serve to enhance the pathways that Coiled-coil domain-containing protein 172 is involved in, possibly by altering the protein's regulatory interactions. LY294002 and Wortmannin, both PI3K inhibitors, could augment Coiled-coil domain-containing protein 172 activity by affecting the PI3K/Akt pathway, which plays a role in the protein's signaling network. The MAPK pathway, targeted by SB203580 and U0126, serves as another route for amplifying Coiled-coil domain-containing protein 172 activity by shifting signaling dynamics in favor of pathways that engage the protein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can reduce competitive phosphorylation, potentially enhancing the functional activity of Coiled-coil domain-containing protein 172 by allowing it to participate more effectively in its associated signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate, through its receptor-mediated signaling, can modulate various intracellular pathways, possibly enhancing the activity of Coiled-coil domain-containing protein 172 by affecting its interaction with other signaling proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, by inhibiting SERCA, raises intracellular calcium levels, potentially enhancing Coiled-coil domain-containing protein 172's activity through calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), and could enhance the activity of Coiled-coil domain-containing protein 172 through PKC-dependent signaling pathways that the protein is involved in. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, as a kinase inhibitor, may reduce negative regulation on pathways, potentially enhancing the activity of Coiled-coil domain-containing protein 172 by altering its interaction with signaling partners. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K, which could enhance the activity of Coiled-coil domain-containing protein 172 through indirect modulation of the PI3K/Akt signaling pathway and its downstream effects. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can indirectly enhance the activity of Coiled-coil domain-containing protein 172 by modulating the PI3K/Akt signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor which could enhance Coiled-coil domain-containing protein 172 activity by modulating MAPK signaling pathways and shifting the signaling balance towards pathways that the protein is involved in. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, potentially enhancing the activity of Coiled-coil domain-containing protein 172 through the activation of calcium-dependent signaling mechanisms. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a non-selective protein kinase inhibitor, could paradoxically enhance the activity of Coiled-coil domain-containing protein 172 by alleviating kinase-mediated suppression of signaling pathways that the protein is involved in. | ||||||