1700010B08Rik Activators
RAI14 activators encompass a diverse array of chemical compounds that exert their influence through a variety of cellular signaling pathways to enhance the functional activity of RAI14. Forskolin augments RAI14's role by increasing cAMP levels, leading to PKA activation; PKA then potentially phosphorylates RAI14, which is key in cellular adhesion mechanisms. PMA and Ionomycin, via the activation of PKC and the elevation of intracellular calcium levels, respectively, bolster RAI14 function in cellular processes that are calcium signaling-dependent. Sphingosine-1-phosphate, by acting on G protein-coupled receptors, initiates signaling cascades that culminate in the activation of RAI14, particularly in the context of cytoskeletal reorganization. The PI3K inhibitor LY294002 and the polyphenol EGCG can lead to a favorable shift in intracellular signaling environments, thereby indirectly enhancing RAI14's activity.
Moreover, compounds such as SB203580 and U0126, which inhibit p38 MAPK and MEK respectively, may reroute cellular signaling in a way that promotes RAI14 activity, especially in regards to stressresponse and cytoskeletal dynamics. Thapsigargin and A23187 exert their effects by disrupting calcium homeostasis, which can lead to the activation of calcium-dependent signaling pathways involving RAI14. This is particularly significant in processes such as cell adhesion and motility, where RAI14 is implicated. Staurosporine, despite its broad-spectrum kinase inhibition, may inadvertently promote RAI14-involved pathways by inhibiting kinases that otherwise suppress these pathways. Lastly, Genistein, through its tyrosine kinase inhibition, may remove competitive inhibition on signaling pathways, thereby enhancing RAI14's functional role within those pathways. Collectively, these activators serve to amplify the functional activity of RAI14 through a multifaceted approach that involves the interplay of intracellular signaling molecules and pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of proteins involved in cellular signaling. This includes pathways where RAI14 is active, thereby potentially enhancing its function in the cell. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This can enhance the activity of RAI14 in cellular processes that are responsive to calcium signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its G protein-coupled receptors to initiate signaling cascades that can lead to actin cytoskeletal rearrangements, where RAI14 may be activated as part of the response to altered cell morphology. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that alters AKT signaling, which can modulate numerous downstream pathways, including those associated with cell adhesion and cytoskeletal reorganization where RAI14 is involved. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, potentially leading to altered signaling pathways that favor the activation of RAI14 by reducing competitive phosphorylations. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which can shift signaling dynamics towards pathways that activate RAI14 function, particularly in stress response and cytoskeletal organization. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which can indirectly enhance RAI14 activity through calcium-dependent signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that, by inhibiting certain kinases, may preferentially activate signaling pathways that involve RAI14 in cellular adhesion and migration. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may enhance the activity of RAI14 by reducing competitive phosphorylations within cell signaling pathways where RAI14 plays a role. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that, like ionomycin, increases intracellular calcium, which can lead to the activation of RAI14 through calcium-dependent signaling pathways. | ||||||