12-LO Inhibitors
Items 1 to 10 of 20 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Esculetin | 305-01-1 | sc-200486 sc-200486A | 1 g 5 g | $43.00 $208.00 | 7 | |
Esculetin acts as a potent modulator of 12-lipoxygenase (12-LO), showcasing unique molecular interactions that enhance its enzymatic activity. Its hydroxyl groups facilitate hydrogen bonding, promoting substrate stabilization and influencing reaction kinetics. The compound's planar structure allows for effective π-π stacking with aromatic residues in the enzyme, potentially altering conformational dynamics and enhancing catalytic efficiency in lipid metabolism pathways. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $114.00 $225.00 | 12 | |
Gossypol exhibits intriguing behavior as a 12-lipoxygenase (12-LO) modulator, characterized by its ability to form stable complexes with the enzyme through hydrophobic interactions. Its unique polyphenolic structure allows for multiple binding sites, which can influence the enzyme's conformational state. This interaction may alter the enzyme's catalytic pathway, affecting the rate of lipid peroxidation and modulating downstream signaling pathways in cellular processes. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $42.00 $62.00 $153.00 $552.00 $988.00 | 10 | |
Ferulic acid acts as a 12-lipoxygenase (12-LO) modulator, showcasing its capacity to engage in specific hydrogen bonding and π-π stacking interactions with the enzyme. Its distinctive phenolic structure facilitates the formation of transient enzyme-substrate complexes, potentially enhancing reaction kinetics. This interaction may lead to altered substrate specificity and modulation of lipid metabolism, influencing various cellular signaling cascades. | ||||||
ETYA | 1191-85-1 | sc-200764 sc-200764A | 20 mg 100 mg | $75.00 $313.00 | 3 | |
ETYA serves as a potent 12-lipoxygenase (12-LO) inhibitor, characterized by its ability to form stable complexes with the enzyme through hydrophobic interactions and steric hindrance. Its unique structure allows for selective binding, which can significantly alter the enzyme's catalytic efficiency. This modulation of enzyme activity may impact lipid peroxidation pathways, leading to changes in cellular redox states and influencing various metabolic processes. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA is a lignan found in the creosote bush and inhibits 12-LO by binding to its active site, thereby preventing the conversion of arachidonic acid to 12-HETE. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid exhibits notable interactions with 12-lipoxygenase (12-LO) through its phenolic hydroxyl groups, which facilitate hydrogen bonding and enhance binding affinity. This compound can alter the enzyme's conformation, affecting its substrate specificity and reaction kinetics. Additionally, caffeic acid's antioxidant properties may influence lipid metabolism by modulating oxidative stress responses, thereby impacting cellular signaling pathways and metabolic regulation. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein demonstrates a unique ability to modulate 12-lipoxygenase activity through its flavonoid structure, which allows for specific π-π stacking interactions with the enzyme's active site. This interaction can lead to conformational changes that influence substrate accessibility and catalytic efficiency. Furthermore, Baicalein's capacity to chelate metal ions may affect the enzyme's stability and reactivity, potentially altering lipid peroxidation pathways and cellular signaling dynamics. | ||||||
Hinokitiol | 499-44-5 | sc-200812 sc-200812A sc-200812B sc-200812C sc-200812D sc-200812E | 50 mg 250 mg 1 g 10 g 50 g 100 g | $63.00 $193.00 $357.00 $714.00 $1533.00 $2244.00 | ||
Hinokitiol exhibits intriguing interactions with 12-lipoxygenase, primarily through its unique hydrophobic and aromatic characteristics. Its molecular structure facilitates strong van der Waals forces and hydrogen bonding with the enzyme, potentially enhancing substrate binding affinity. This interaction may influence the enzyme's conformational dynamics, affecting its catalytic turnover rate. Additionally, Hinokitiol's antioxidant properties could modulate oxidative stress responses, impacting lipid metabolism pathways. | ||||||
ETI | 13488-22-7 | sc-200762 sc-200762A | 1 mg 10 mg | $85.00 $611.00 | ||
ETI acts as a potent 12-lipoxygenase inhibitor, characterized by its ability to form stable complexes with the enzyme's active site. Its structural features promote specific electrostatic interactions and hydrophobic contacts, which can alter the enzyme's conformational stability. This modulation may lead to a significant decrease in reaction kinetics, affecting the overall lipid peroxidation process. Furthermore, ETI's unique reactivity as an acid halide allows for selective acylation, influencing downstream metabolic pathways. | ||||||
8,11,14-Eicosatriynoic Acid | 34262-64-1 | sc-221152 sc-221152A | 1 mg 5 mg | $132.00 $595.00 | ||
8,11,14-Eicosatriynoic Acid exhibits unique properties as a 12-lipoxygenase modulator, engaging in specific molecular interactions that enhance its inhibitory effects. Its elongated carbon chain facilitates unique steric hindrance, impacting enzyme accessibility and altering catalytic efficiency. The compound's reactivity profile allows for targeted interactions with lipid substrates, potentially redirecting metabolic flux and influencing cellular signaling pathways. This specificity underscores its role in lipid metabolism dynamics. | ||||||