1190003J15Rik Inhibitors
Chemical inhibitors of the protein 1190003J15Rik act through various mechanisms to impede its function within cellular signaling pathways. Wortmannin and LY294002 are potent inhibitors of phosphoinositide 3-kinases (PI3K), which are integral to the activation of the Akt signaling pathway. By obstructing PI3K, these compounds effectively prevent the phosphorylation and subsequent activation of Akt, resulting in the inhibition of any downstream effectors, including the protein 1190003J15Rik. Similarly, Rapamycin directly inhibits the mechanistic target of rapamycin (mTOR), a central protein in the regulation of cell growth and metabolism that is also associated with the PI3K/Akt pathway. As mTOR acts downstream of Akt, Rapamycin's action would lead to the suppression of the protein 1190003J15Rik by impeding the pathway that converges on its activation.
Complementary to these, PD98059 and U0126 specifically target MEK1/2 within the MAPK/ERK pathway. Inhibition of MEK prevents the activation of ERK, which may indirectly affect the function of the protein 1190003J15Rik if ERK signaling is required for its activity. SB203580 and PD169316 both target p38 MAP kinase, another MAPK pathway component, potentially leading to the downregulation of 1190003J15Rik if it is a downstream target. Additionally, SP600125 impedes the function of c-Jun N-terminal kinase (JNK), which could similarly impact the protein 1190003J15Rik if it is part of the JNK signaling cascade. PP2, a Src family kinase inhibitor, also serves to disrupt signaling pathways that may activate 1190003J15Rik, thereby inhibiting its function. Meanwhile, Y-27632 targets Rho-associated protein kinase (ROCK), and its inhibitory action can suppress 1190003J15Rik if it is part of the Rho/ROCK signaling pathway. Lastly, Bisindolylmaleimide, acting as an inhibitor of Protein Kinase C (PKC), can inhibit 1190003J15Rik by halting the PKC-mediated signaling processes that are essential for the protein's function. Each of these inhibitors, by targeting specific kinases or enzymes, disrupts the signaling pathways that are crucial for the activation and function of the protein 1190003J15Rik.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinases (PI3K), which are upstream of Akt signaling pathways. 1190003J15Rik, being a part of the Akt pathway, would be functionally inhibited as a result of the prevention of Akt activation due to PI3K inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of PI3K, leading to the suppression of the PI3K/Akt pathway. This chemical would inhibit the functionality of 1190003J15Rik by blocking the activation of the Akt pathway, which is necessary for the full functionality of the protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR (mechanistic target of rapamycin), a key regulator of cell growth and metabolism, known to interact with the PI3K/Akt pathway. By inhibiting mTOR, the downstream effect would be the functional inhibition of 1190003J15Rik, assuming it is a downstream effector in this signaling cascade. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which is involved in the MAPK/ERK pathway. The MAPK/ERK pathway often crosstalks with the PI3K/Akt pathway, where 1190003J15Rik is involved. Inhibition of MEK would therefore inhibit ERK activation and potentially inhibit 1190003J15Rik function downstream. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which might be involved in the same signaling pathways as 1190003J15Rik. Inhibition of p38 MAP kinase would lead to functional inhibition of 1190003J15Rik by preventing its activation through this stress response pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK), a component of MAPK signaling pathways. Inhibition of JNK could lead to functional inhibition of 1190003J15Rik if the protein is a downstream target in the JNK signaling cascade. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src family kinase inhibitor, and since Src kinases can interact with multiple signaling pathways including PI3K/Akt, inhibition of Src could result in the functional inhibition of 1190003J15Rik if it relies on Src signaling for its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. The MAPK pathway has interactions with the PI3K/Akt pathway, and the functional inhibition of MEK1/2 would lead to the functional inhibition of 1190003J15Rik if it is part of the MAPK/ERK signaling that converges on the PI3K/Akt pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). If 1190003J15Rik functions downstream of Rho/ROCK signaling, then the inhibition of ROCK by Y-27632 would lead to the functional inhibition of 1190003J15Rik. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. Inhibition of MEK by SL327 would prevent the phosphorylation and activation of ERK, potentially leading to the functional inhibition of 1190003J15Rik if it operates downstream of this pathway. | ||||||