Thrombospondin 1 Antibody (MS-421): sc-81755

Thrombospondin 1 Antibody (MS-421) is a mouse monoclonal IgG1 kappa light chain antibody, meticulously developed against the reduced and alkylated form of human Thrombospondin 1 (TSP-1), also known as THBS1. Thrombospondin 1 is a pivotal extracellular glycoprotein involved in mediating cell-to-cell and cell-to-matrix interactions, playing essential roles in angiogenesis, wound healing, and immune response regulation. TSP-1 is crucial for platelet aggregation, cell adhesion, migration, and the progression of cells through the growth cycle, thereby significantly influencing tissue development and repair processes. Additionally, TSP-1 modulates the activation of transforming growth factor-beta (TGF-β), a key factor in cellular growth and differentiation, highlighting its importance in maintaining cellular homeostasis. Anti-Thrombospondin 1 antibody (MS-421) demonstrates remarkable species reactivity, effectively recognizing both reduced and non-reduced forms of TSP-1 across mouse, rat, human, equine, bovine, and porcine origins. This broad reactivity makes anti-Thrombospondin 1 antibody (MS-421) an invaluable tool for various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Thrombospondin 1 monoclonal antibody (MS-421) supports advanced research into TSP-1′s roles in cardiovascular diseases, cancer, and inflammatory conditions. Anti-Thrombospondin 1 antibody (MS-421) helps researchers gain deeper insights into the mechanisms and therapeutic potential of TSP-1 in regulating cellular environments and extracellular matrix dynamics, ultimately contributing to the development of targeted treatments and interventions.

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Thrombospondin 1 Antibody (MS-421) References:

1. Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.  |  Miyata, Y. and Sakai, H. 2013. Int J Mol Sci. 14: 12249-72. PMID: 23749112
2. Thrombospondin 1 Suppresses Insulin Signaling in C2C12 Myotubes.  |  Matsugi, K., et al. 2016. Kobe J Med Sci. 62: E13-8. PMID: 27492207
3. Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease.  |  Rogers, NM., et al. 2017. Cardiovasc Res. 113: 858-868. PMID: 28472457
4. Thrombospondin-1 inhibits ossification of tissue engineered cartilage constructed by ADSCs.  |  Xie, A., et al. 2017. Am J Transl Res. 9: 3487-3498. PMID: 28804565
5. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome.  |  Torres, MD., et al. 2018. Free Radic Biol Med. 114: 10-14. PMID: 28965914
6. Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves.  |  Tatematsu, Y., et al. 2018. Int J Mol Sci. 19: PMID: 30332778
7. Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease.  |  Murphy-Ullrich, JE. 2019. J Histochem Cytochem. 67: 683-699. PMID: 31116066
8. Thrombospondin-1 mediates Drp-1 signaling following ischemia reperfusion in the aging heart.  |  Kelm, NQ., et al. 2020. FASEB Bioadv. 2: 304-314. PMID: 32395703
9. Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently.  |  Touhami, S., et al. 2022. Int J Mol Sci. 23: PMID: 35054863
10. [Corrigendum] Role of Thrombospondin‑1 in sepsis‑induced myocardial injury.  |  Xie, Y., et al. 2023. Mol Med Rep. 27: PMID: 37083065

The preferred Thrombospondin 1 antibody is Thrombospondin 1 Antibody (A6.1): sc-59887.