Thrombospondin 1 Antibody (C-8): sc-393504
- Thrombospondin 1 Antibody (C-8) is a mouse monoclonal IgG2b κ Thrombospondin 1 antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 22-51 near the N-terminus of Thrombospondin 1 of human origin
- Thrombospondin 1 Antibody (C-8) is recommended for detection of Thrombospondin 1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- Anti-Thrombospondin 1 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Thrombospondin 1 Antibody (C-8) for WB applications. This reagent is now offered in a bundle with Thrombospondin 1 Antibody (C-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
Thrombospondin 1 Antibody (C-8) is a mouse monoclonal IgG2b kappa light chain antibody designed to target an epitope mapping between amino acids 22-51 near the N-terminus of human Thrombospondin 1 (TSP-1), also known as THBS1. Thrombospondin 1 is a vital extracellular matrix glycoprotein involved in critical cellular functions such as cell-to-cell and cell-to-matrix communication, angiogenesis, wound healing, and tissue remodeling. By mediating interactions with key proteins like CD36, CD47, and various integrins, TSP-1 plays an essential role in regulating cellular adhesion, migration, and proliferation, which are crucial for maintaining tissue integrity and facilitating responses to injury and inflammation. Additionally, TSP-1 is instrumental in platelet aggregation and in the activation of transforming growth factor-beta (TGF-β), a key cytokine involved in cellular growth and differentiation, underscoring its importance in both physiological and pathological processes. TSP-1 can also influence TGF-β activation through mechanisms that modulate its latent form, highlighting its central role in regulating extracellular matrix remodeling and immune responses. Anti-TSP-1 antibody (C-8) exhibits broad species reactivity, effectively recognizing TSP-1 in mouse, rat, and human samples, as well as in equine, bovine, and porcine species, making it a versatile tool for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). By specifically targeting the N-terminal region of TSP-1, TSP-1 monoclonal antibody (C-8) ensures high specificity and sensitivity, enabling accurate detection and analysis of TSP-1 in various experimental settings. Anti-TSP-1 antibody (C-8) facilitates comprehensive studies into the molecular mechanisms and therapeutic potential of TSP-1, supporting the development of targeted treatments aimed at modulating its functions in diverse biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombospondin 1 Antibody (C-8) | sc-393504 | 200 µg/ml | $322.00 | |||
Thrombospondin 1 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-523966 | 200 µg Ab, 40 µg BP | $361.00 | |||
Thrombospondin 1 Antibody (C-8) AC | sc-393504 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Thrombospondin 1 Antibody (C-8) HRP | sc-393504 HRP | 200 µg/ml | $322.00 | |||
Thrombospondin 1 Antibody (C-8) FITC | sc-393504 FITC | 200 µg/ml | $336.00 | |||
Thrombospondin 1 Antibody (C-8) PE | sc-393504 PE | 200 µg/ml | $349.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 488 | sc-393504 AF488 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 546 | sc-393504 AF546 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 594 | sc-393504 AF594 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 647 | sc-393504 AF647 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 680 | sc-393504 AF680 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 Antibody (C-8) Alexa Fluor® 790 | sc-393504 AF790 | 200 µg/ml | $364.00 | |||
Thrombospondin 1 (C-8) Neutralizing Peptide | sc-393504 P | 100 µg/0.5 ml | $69.00 |