Thrombospondin 1 Inhibitors
Common Thrombospondin 1 Inhibitors include, but are not limited to Dipyridamole CAS 58-32-2, Fumagillin CAS 23110-15-8, (-)-Epigallocatechin Gallate CAS 989-51-5, Nifedipine CAS 21829-25-4 and Cilostazol CAS 73963-72-1.
Thrombospondin 1 inhibitors belong to a specialized chemical class of compounds that selectively target and modulate the activity of TSP-1, a multifunctional glycoprotein present in the extracellular matrix and secreted by various cell types, including platelets. TSP-1 plays a central role in mediating cell-matrix interactions, angiogenesis, tissue remodeling, cell adhesion, and immune responses. It acts through interactions with specific cell surface receptors, notably integrins and CD36, as well as other binding partners within the extracellular environment. By inhibiting TSP-1, these compounds aim to disrupt its interactions with cell surface receptors and other binding partners, which can have wide-ranging effects on cellular responses to the surrounding extracellular matrix. TSP-1 inhibitors impact various cellular functions, including cell adhesion, migration, proliferation, and survival. Additionally, TSP-1 is involved in regulating angiogenesis, the process of forming new blood vessels from pre-existing ones, which is essential for various physiological and pathological processes.
TSP-1 inhibitors represent valuable tools for researchers to investigate the diverse functions of TSP-1 and explore its implications in numerous physiological and disease-related processes. By selectively inhibiting TSP-1, scientists can study the intricate regulatory networks governed by this protein and its role in maintaining tissue homeostasis and mediating responses to injury and inflammation. The specific chemical structures and mechanisms of action of TSP-1 inhibitors can vary widely, and researchers continuously seek to optimize these compounds to enhance their selectivity and efficacy in modulating TSP-1 activity. Understanding the precise interactions and signaling pathways affected by TSP-1 inhibition is crucial for comprehending the broader impact of this glycoprotein on cellular and tissue dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole is an agent with pleiotropic effects, including the inhibition of platelet aggregation and anti-inflammatory properties. It has been shown to modulate TSP-1 expression and secretion. May involve indirect modulation of transcription factors or signaling pathways. Dipyridamole's potential to modulate TSP-1 levels may impact processes such as angiogenesis and tissue remodeling. | ||||||
Fumagillin | 23110-15-8 | sc-200377 sc-200377A sc-200377B sc-200377C sc-200377D | 1 mg 5 mg 25 mg 100 mg 500 mg | $102.00 $385.00 $530.00 $1336.00 $5110.00 | 1 | |
Fumagillin is a naturally occurring compound that inhibits angiogenesis by targeting methionine aminopeptidase 2 (MetAP2). TSP-1 expression can be regulated by MetAP2. As a consequence, Fumagillin indirectly affects TSP-1 levels. By inhibiting TSP-1 expression, Fumagillin may impact processes such as angiogenesis and tissue remodeling. Fumagillin has been studied for its potential therapeutic use in cancer and other angiogenesis-related diseases. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea with antioxidant and anti-inflammatory properties. It has been reported to downregulate TSP-1 expression in certain experimental models. The mechanism by which EGCG affects TSP-1 expression is not fully understood, but it may involve inhibition of pro-inflammatory signaling pathways or transcription factors that regulate TSP-1 gene expression. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker and it has been reported to reduce TSP-1 expression in certain experimental models. The mechanism by which Nifedipine affects TSP-1 expression is not fully understood but may involve indirect modulation of transcription factors or signaling pathways. By reducing TSP-1 levels, Nifedipine may impact processes such as angiogenesis and tissue remodeling. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $85.00 $325.00 $1072.00 | 16 | |
Docetaxel has been reported to modulate TSP-1 expression in certain experimental models. The exact mechanism by which Docetaxel affects TSP-1 expression is not fully understood but may involve indirect modulation of transcription factors or signaling pathways. By modulating TSP-1 levels, Docetaxel may impact processes such as angiogenesis and tissue remodeling. | ||||||