Thrombospondin 1 Antibody (A4.1): sc-59886
- Thrombospondin 1 Antibody (A4.1) is a mouse monoclonal IgM κ, cited in 22 publications, provided at 200 µg/ml
- raised against calcium-replete native purified Thrombospondin of human origin
- recommended for detection of Thrombospondin 1 of mouse, rat, human and bovine origin by WB, IP, IF and FCM; non cross-reactive with Fibronectin, fibrinogen or Von Willebrand factor
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Thrombospondin 1 (C-8): sc-393504 for Thrombospondin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Thrombospondin 1 Antibody (A4.1). This work is in progress.
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Thrombospondin 1 Antibody (A4.1) is a mouse monoclonal IgM kappa light chain antibody designed to target Thrombospondin 1 (TSP-1). TSP-1 is a key extracellular glycoprotein involved in cell-to-cell and cell-to-matrix signaling, playing a vital role in processes such as platelet aggregation, cell adhesion, migration, and the regulation of tissue development, repair, and angiogenesis. TSP-1 also plays a role in inhibiting angiogenesis in certain contexts and modulating the activity of growth factors like TGF-β. Anti-Thrombospondin 1 antibody (A4.1) is raised against calcium-replete native purified human Thrombospondin 1 and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM) applications. Thrombospondin 1 (A4.1) antibody demonstrates broad species reactivity, recognizing Thrombospondin 1 from mouse, rat, human, and bovine origins. The ability of TSP-1 to influence angiogenesis, wound healing, and cancer metastasis underscores its importance in both physiological and pathological contexts. Anti-Thrombospondin 1 antibody (A4.1) enables researchers to accurately investigate the diverse functions of TSP-1, facilitating advancements in understanding cellular mechanisms and developing therapeutic strategies. Thrombospondin 1 (A4.1) monoclonal antibody is an essential tool for studies focused on the intricate roles of TSP-1 in maintaining cellular homeostasis and responding to tissue injury.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thrombospondin 1 Antibody (A4.1) References:
- Thrombospondin-1 in ocular surface health and disease. | Foulsham, W., et al. 2019. Ocul Surf. 17: 374-383. PMID: 31173926
- Thrombospondin 1 in Metabolic Diseases. | Gutierrez, LS. and Gutierrez, J. 2021. Front Endocrinol (Lausanne). 12: 638536. PMID: 33854480
- Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine. | Kale, A., et al. 2021. Int J Mol Sci. 22: PMID: 33920030
- Functions of Thrombospondin-1 in the Tumor Microenvironment. | Kaur, S., et al. 2021. Int J Mol Sci. 22: PMID: 33925464
- TGF-β promotes microtube formation in glioblastoma through thrombospondin 1. | Joseph, JV., et al. 2022. Neuro Oncol. 24: 541-553. PMID: 34543427
- ECM stiffness-tuned exosomes drive breast cancer motility through thrombospondin-1. | Patwardhan, S., et al. 2021. Biomaterials. 279: 121185. PMID: 34808560
- The matricellular protein thrombospondin-1 in lung inflammation and injury. | Tabary, M., et al. 2022. Am J Physiol Cell Physiol. 323: C857-C865. PMID: 35912991
- Emerging functions of thrombospondin-1 in immunity. | Kaur, S. and Roberts, DD. 2024. Semin Cell Dev Biol. 155: 22-31. PMID: 37258315
- CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis. | Singla, B., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 1234-1250. PMID: 37259865
- Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia. | Hu, H., et al. 2024. Adv Sci (Weinh). 11: e2309002. PMID: 38569496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombospondin 1 Antibody (A4.1) | sc-59886 | 200 µg/ml | $322.00 | |||
Thrombospondin 1 Antibody (A4.1) FITC | sc-59886 FITC | 200 µg/ml | $336.00 | |||
Thrombospondin 1 Antibody (A4.1) PE | sc-59886 PE | 200 µg/ml | $349.00 |