Date published: 2025-9-6

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CTLA-4 抗体 (1B8): sc-18829

4.0(2)
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说明书
  • CTLA-4抗体(1B8)是一种亚美尼亚仓鼠单克隆 IgG,在200 µg/ml处提供
  • 针对融合鼠 CTLA-4 和鼠 IgG2a 的细胞外部分产生
  • 推荐用于 mouse 来源的CTLA-4 IP, IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 还提供无叠氮化物,用于抑制CTLA-4阳性细胞与活化B细胞上的B7抗原相互作用,sc-18829 L,200 µg/0.1 ml
  • 看 CTLA-4 (F-8): sc-376016,可查看有标记的 CTLA-4 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成CTLA-4 抗体 (1B8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    T细胞增殖和淋巴因子产生是由抗原占据TCR引发的,其后由抗原呈递细胞表达的配体传递一个佐助信号。B7相关的细胞表面蛋白CD80(B7-1)和CD86(B7-2)在抗原呈递细胞上表达,结合同源的T细胞受体CD28和CTLA-4(细胞毒性T淋巴细胞相关蛋白-4),触发共刺激信号以实现最佳的T细胞激活。CTLA-4与CD28的总氨基酸同源性为31%,据推测CD28和CTLA-4在功能上是冗余的。SLAM是T细胞上一种新发现的受体,结合后可以以CD28独立的方式增强T细胞扩增。B7,又称BB1,是另一种结合CD28和CTLA-4的配体或反受体,表达于抗原呈递细胞上。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    CTLA-4 抗体 (1B8)

    sc-18829
    200 µg/ml
    $316.00

    CTLA-4 抗体 (1B8) FITC

    sc-18829 FITC
    200 µg/ml
    $330.00

    CTLA-4 抗体 (1B8) L

    sc-18829 L
    200 µg/0.1 ml
    $316.00

    CTLA-4 抗体 (1B8) PE

    sc-18829 PE
    200 µg/ml
    $343.00

    Can CTLA-4 (1B8): sc-18829 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

    Asked by: Cweed
    Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CTLA-4 (1B8): sc-18829 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
    Answered by: Technical Support
    Date published: 2017-02-24
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    Rated 5 out of 5 by from Nice IP staining imagesWe used this antibody for Immunoperoxidase staining and were able t get nice images from the staining results in mouse tissue
    Date published: 2017-02-06
    Rated 3 out of 5 by from Produced acceptable immunoperoxidase membraneProduced acceptable immunoperoxidase membrane staining in formalin fixed, paraffin-embedded mouse lymphoma tissue. -SCBT QC
    Date published: 2013-01-30
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    CTLA-4 抗体 (1B8) is rated 4.0 out of 5 by 2.
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