caspase-8 Anticorpo (8CSP01): sc-81661
- caspase-8 Anticorpo 8CSP01é um anticorpo monoclonal produzido em camundongo IgG1 κ, citado em 4 publicações, fornecido em 200 µg/ml
- ativado contra recombinante caspase-8 de comprimento total de origem human
- recomendado para a detecção de caspase-8 de mouse, rat e human origem em
- See caspase-8 (8CSP03): sc-56070 for additional antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP e m-IgGκ BP-HRP são os reagentes de deteção secundários preferidos para caspase-8 Antibody (8CSP01) para aplicações WB. Estes reagentes são agora oferecidos em pacotes com caspase-8 Antibody (8CSP01)(ver informações de encomenda abaixo).
LINKS RÁPIDOS
VEJA TAMBÉM
Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
Informacoes sobre ordens
| Nome do Produto | Numero de Catalogo | UNID | Preco | Qde | FAVORITOS | |
caspase-8 Anticorpo (8CSP01) | sc-81661 | 200 µg/ml | $316.00 | |||
Pacote do caspase-8 (8CSP01): m-IgG Fc BP-HRP | sc-537254 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pacote do caspase-8 (8CSP01): m-IgGκ BP-HRP | sc-534479 | 200 µg Ab; 40 µg BP | $354.00 | |||
Pacote do caspase-8 (8CSP01): m-IgG1 BP-HRP | sc-545109 | 200 µg Ab; 20 µg BP | $354.00 |