ZPR1 Antibody (B-12): sc-398491

ZPR1 Antibody (B-12) is a mouse monoclonal IgG2b antibody that detects ZPR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZPR1 antibody (B-12) recognizes ZPR1, a zinc finger-containing protein that plays a crucial role in cellular signaling by interacting with the epidermal growth factor receptor (EGFR). This interaction is significant because ZPR1 is involved in the regulation of EGFR signaling pathways, which are essential for cell growth and differentiation. Upon stimulation with epidermal growth factor, ZPR1′s affinity for EGFR decreases, resulting in translocation to the nucleus, where ZPR1 may influence gene expression and cellular responses. The zinc finger motif of ZPR1 is critical for binding to EGFR′s intracellular tyrosine kinase domain, highlighting the importance of this structural feature in mediating protein-protein interactions that are vital for cellular communication and function. ZPR1′s ability to modulate EGFR signaling underscores its potential as a target for therapeutic interventions in diseases characterized by aberrant growth factor signaling.

The preferred ZPR1 antibody is ZPR1 Antibody (C-1): sc-398241.