ZPR1 Antibody (C-1): sc-398241
- ZPR1 Antibody (C-1) is a mouse monoclonal IgG2a κ ZPR1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 430-459 at the C-terminus of ZPR1 of mouse origin
- ZPR1 Antibody (C-1) is recommended for detection of ZPR1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ZPR1 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398241 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for ZPR1 Antibody (C-1) for WB applications. These reagents are now offered in bundles with ZPR1 Antibody (C-1) (see ordering information below).
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ZPR1 Antibody (C-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZPR1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZPR1 Antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZPR1 plays a crucial role in cellular signaling, particularly in the context of the epidermal growth factor receptor (EGFR) pathway. ZPR1 contains zinc finger motifs that facilitate binding to the intracellular tyrosine kinase domain of EGFR, which is essential for modulating receptor activity. Upon stimulation with epidermal growth factor, ZPR1′s affinity for EGFR decreases, resulting in ZPR1 translocation to the nucleus. This dynamic interaction underscores ZPR1′s importance in regulating cellular responses to growth factors, as well as potential implications in cancer biology, where aberrations in EGFR signaling pathway are often observed.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZPR1 Antibody (C-1) References:
- Epidermal growth factor, its receptor, and related proteins. | Carpenter, G. and Zendegui, JG. 1986. Exp Cell Res. 164: 1-10. PMID: 3007185
- Receptors for epidermal growth factor and other polypeptide mitogens. | Carpenter, G. 1987. Annu Rev Biochem. 56: 881-914. PMID: 3039909
- In vivo aspects of urogastrone-epidermal growth factor. | Gregory, H. 1985. J Cell Sci Suppl. 3: 11-7. PMID: 3914989
- The primary structure of epidermal growth factor. | Savage, CR., et al. 1972. J Biol Chem. 247: 7612-21. PMID: 4636327
- The epidermal growth factor receptor gene and its product. | Hunter, T. Nature. 311: 414-6. PMID: 6090939
- Human transforming growth factors induce tyrosine phosphorylation of EGF receptors. | Reynolds, FH., et al. 1981. Nature. 292: 259-62. PMID: 6265789
- Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. | Galcheva-Gargova, Z., et al. 1996. Science. 272: 1797-802. PMID: 8650580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZPR1 Antibody (C-1) | sc-398241 | 200 µg/ml | $322.00 | |||
ZPR1 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-526301 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZPR1 Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-546571 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZPR1 Antibody (C-1) X | sc-398241 X | 200 µg/0.1 ml | $322.00 | |||
ZPR1 Antibody (C-1) AC | sc-398241 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZPR1 Antibody (C-1) HRP | sc-398241 HRP | 200 µg/ml | $322.00 | |||
ZPR1 Antibody (C-1) FITC | sc-398241 FITC | 200 µg/ml | $336.00 | |||
ZPR1 Antibody (C-1) PE | sc-398241 PE | 200 µg/ml | $349.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 488 | sc-398241 AF488 | 200 µg/ml | $364.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 546 | sc-398241 AF546 | 200 µg/ml | $364.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 594 | sc-398241 AF594 | 200 µg/ml | $364.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 647 | sc-398241 AF647 | 200 µg/ml | $364.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 680 | sc-398241 AF680 | 200 µg/ml | $364.00 | |||
ZPR1 Antibody (C-1) Alexa Fluor® 790 | sc-398241 AF790 | 200 µg/ml | $364.00 | |||
ZPR1 (C-1) Neutralizing Peptide | sc-398241 P | 100 µg/0.5 ml | $69.00 |