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ZBP-89 Antibody (E-6): sc-398148

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Datasheets
  • ZBP-89 Antibody (E-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 675-702 near the C-terminus of ZBP-89 of human origin
  • recommended for detection of ZBP-89 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
  • TransCruz reagent for ChIP application (sc-398148 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZBP-89 Antibody (E-6) for WB applications. These reagents are now offered in bundles with ZBP-89 Antibody (E-6) (see ordering information below).

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ZBP-89 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects ZBP-89 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZBP-89, also known as BFCOL1, BERF1, and ZNF 148, is a zinc finger transcription factor that plays a crucial role in regulating gene expression, particularly in cell differentiation and proliferation. ZBP-89 is primarily located in the nucleus, where ZBP-89 functions as a transcriptional repressor, binding to GC-rich DNA elements in the promoters of various genes, including those involved in cell cycle regulation and apoptosis. ZBP-89′s ability to interact with p53 protein is particularly significant, as ZBP-89 not only influences the expression of cyclin-dependent kinase inhibitor p21 but also modulates p53′s nuclear export, thereby impacting cellular responses to stress and DNA damage. Elevated levels of ZBP-89 have been associated with growth arrest and apoptosis in human gastrointestinal cells, highlighting ZBP-89′s importance in cancer biology and potential therapeutic applications. Anti-ZBP-89 antibody (E-6) is an essential tool for researchers studying the intricate mechanisms of gene regulation and the role of transcription factors in cellular processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

ZBP-89 Antibody (E-6) References:

  1. The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene.  |  Park, H., et al. 2003. Blood. 101: 894-902. PMID: 12393719
  2. Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89.  |  Chen, GG., et al. 2003. Am J Pathol. 162: 1823-9. PMID: 12759240
  3. Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.  |  Bai, L., et al. 2006. Gastroenterology. 131: 841-52. PMID: 16952553
  4. ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate.  |  Bai, L. and Merchant, JL. 2007. Biochem Biophys Res Commun. 359: 817-21. PMID: 17560543
  5. The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression.  |  Wu, Y., et al. 2007. Genes Cells. 12: 905-18. PMID: 17663720
  6. Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89.  |  Chupreta, S., et al. 2007. J Biol Chem. 282: 36155-66. PMID: 17940278
  7. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells.  |  Petrovic, I., et al. 2009. Mol Biol Rep. 36: 993-1000. PMID: 18496767
  8. NF-kappaB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter.  |  Borghaei, RC., et al. 2009. Biochem Biophys Res Commun. 382: 269-73. PMID: 19275880
  9. ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.  |  Chen, GG., et al. 2009. Cancer Lett. 283: 52-8. PMID: 19362768
  10. The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression.  |  Law, DJ., et al. 1998. Mamm Genome. 9: 165-7. PMID: 9457682

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZBP-89 Antibody (E-6)

sc-398148
200 µg/ml
$316.00

ZBP-89 Antibody (E-6): m-IgG Fc BP-HRP Bundle

sc-538379
200 µg Ab; 10 µg BP
$354.00

ZBP-89 Antibody (E-6): m-IgGκ BP-HRP Bundle

sc-535983
200 µg Ab; 40 µg BP
$354.00

ZBP-89 Antibody (E-6): m-IgG1 BP-HRP Bundle

sc-545672
200 µg Ab; 20 µg BP
$354.00

ZBP-89 (E-6) Neutralizing Peptide

sc-398148 P
100 µg/0.5 ml
$68.00

ZBP-89 Antibody (E-6) X

sc-398148 X
200 µg/0.1 ml
$316.00

What application is the blocking peptide sc-398148 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Nice Western blot data of ZBPNice Western blot data of ZBP-89 expression in non-transfected and mouse ZBP-89 transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-02-23
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ZBP-89 Antibody (E-6) is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_16, h_8
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