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ZBP-89 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects ZBP-89 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZBP-89, also known as BFCOL1, BERF1, and ZNF 148, is a zinc finger transcription factor that plays a crucial role in regulating gene expression, particularly in cell differentiation and proliferation. ZBP-89 is primarily located in the nucleus, where ZBP-89 functions as a transcriptional repressor, binding to GC-rich DNA elements in the promoters of various genes, including those involved in cell cycle regulation and apoptosis. ZBP-89′s ability to interact with p53 protein is particularly significant, as ZBP-89 not only influences the expression of cyclin-dependent kinase inhibitor p21 but also modulates p53′s nuclear export, thereby impacting cellular responses to stress and DNA damage. Elevated levels of ZBP-89 have been associated with growth arrest and apoptosis in human gastrointestinal cells, highlighting ZBP-89′s importance in cancer biology and potential therapeutic applications. Anti-ZBP-89 antibody (E-6) is an essential tool for researchers studying the intricate mechanisms of gene regulation and the role of transcription factors in cellular processes.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZBP-89 Antibody (E-6) | sc-398148 | 200 µg/ml | $316.00 | |||
ZBP-89 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-538379 | 200 µg Ab; 10 µg BP | $354.00 | |||
ZBP-89 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-535983 | 200 µg Ab; 40 µg BP | $354.00 | |||
ZBP-89 Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-545672 | 200 µg Ab; 20 µg BP | $354.00 | |||
ZBP-89 (E-6) Neutralizing Peptide | sc-398148 P | 100 µg/0.5 ml | $68.00 | |||
ZBP-89 Antibody (E-6) X | sc-398148 X | 200 µg/0.1 ml | $316.00 |