ZBP-89 Activators
The chemical class referred to as ZBP-89 Activators encompasses a diverse group of compounds that, while not directly interacting with ZBP-89, can modulate cellular pathways and processes that ultimately influence the activity of this zinc finger protein. These compounds operate through distinct mechanisms, affecting various cellular signaling pathways and transcription factors, which in turn can alter the functional state of ZBP-89.
The primary mechanisms through which these chemicals exert their influence include modulation of gene expression, alteration of signaling pathways like NF-κB, PI3K/Akt, JNK, and MAPK/ERK, and effects on chromatin remodeling and histone modification. For instance, compounds like Retinoic Acid and EGCG indirectly affect ZBP-89 by modulating the JNK and NF-κB pathways, respectively, which are known to interact with transcription factors associated with ZBP-89. Similarly, Curcumin and Resveratrol impact the PI3K/Akt and sirtuin pathways, respectively, creating a cascade of cellular events that can influence the regulatory roles of ZBP-89 in gene expression and cell cycle processes. Furthermore, the use of histone deacetylase inhibitors like Sodium Butyrate exemplifies the indirect approach to influencing ZBP-89's activity by altering chromatin structure and gene expression patterns. Inhibitors of key kinases and enzymes, such as Forskolin, Lithium Chloride, and Rapamycin, demonstrate the broad spectrum of cellular processes that can be modulated to indirectly affect the activity of ZBP-89.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through retinoic acid receptors. This action influences the JNK pathway, which can regulate the activity of AP-1, a transcription factor known to interact with ZBP-89, leading to its activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol in green tea, has been shown to modulate the NF-κB pathway. NF-κB, in turn, regulates various genes involved in inflammation and cell survival, potentially impacting ZBP-89 activity indirectly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, from turmeric, affects the PI3K/Akt pathway. This pathway is crucial for cellular survival and proliferation. Altering PI3K/Akt can have downstream effects on transcription factors and coactivators interacting with ZBP-89. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a compound in red wine, modulates sirtuin activity, particularly SIRT1. SIRT1 influences chromatin remodeling and gene expression, which can indirectly affect ZBP-89's role in transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor, altering chromatin structure and gene expression. This can indirectly influence ZBP-89's activity in gene regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can modulate various signaling pathways, potentially impacting ZBP-89's transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase involved in Wnt signaling. Although Wnt itself doesn't activate ZBP-89, downstream effects of Wnt signaling modulation can influence ZBP-89 activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Found in cruciferous vegetables, sulforaphane influences the Nrf2 pathway, which is involved in the cellular response to oxidative stress. This can indirectly affect ZBP-89's regulatory roles. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By modulating PI3K/Akt signaling, it can influence various transcription factors and cofactors that may interact with ZBP-89. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, affecting the MAPK/ERK pathway. This pathway's modulation can alter the activity of transcription factors that work in concert with ZBP-89. | ||||||