YTHDF3 Antibody (F-2): sc-377119

YTHDF3 Antibody (F-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects YTHDF3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-YTHDF3 antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. YTHDF3, consisting of 585 amino acids, plays a crucial role in RNA metabolism, particularly in regulating mRNA stability and translation. YTHDF3 interacts with N6-methyladenosine (m6A) modified RNA, which is essential for various cellular processes, including gene expression and cellular response to stress. YTHDF3′s ability to bind to m6A-modified transcripts highlights YTHDF3′s importance in post-transcriptional regulation, influencing processes such as cell differentiation and proliferation. YTHDF3 is encoded on chromosome 8, a region associated with several genetic disorders, including certain leukemias and psychiatric conditions. Understanding YTHDF3′s function and interactions with m6A-modified RNA can provide insights into YTHDF3′s role in health and disease, making YTHDF3 monoclonal antibody (F-2) a valuable tool for researchers studying RNA biology and related pathways.

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YTHDF3 Antibody (F-2) References:

1. Chromosomes 8 and 10 workshop.  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
2. Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
3. YTH: a new domain in nuclear proteins.  |  Stoilov, P., et al. 2002. Trends Biochem Sci. 27: 495-7. PMID: 12368078
4. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
5. DNA sequence and analysis of human chromosome 8.  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
6. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
7. Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis.  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002
8. Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry.  |  Yu, F., et al. 2009. Acta Crystallogr D Biol Crystallogr. 65: 212-9. PMID: 19237743

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-YTHDF3 Antibody (F-2) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-YTHDF3 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

YTHDF3 Antibody (F-2) Specifications

Alternate Product Name: YTHDF3

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 85-119

Epitope Target: YTHDF3

Epitope Species: human

Product Reactivity/Detection: YTHDF3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for YTHDF3 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin