X11γ Antibody (D-3): sc-376926

X11γ Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects X11γ in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11γ, a member of the X11 family of proteins, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11γ is primarily located in the cytoplasm and at the synapses of neurons, where X11γ interacts with β-APP to modulate internalization and processing. X11γ′s cellular location influences synaptic function and neuronal health, as dysregulation of β-APP processing can lead to the accumulation of amyloid plaques, a hallmark of Alzheimer′s pathology. By binding to the YENPTY motif of β-APP, X11γ not only reduces the secretion of β-APP but also slows down the pathways that lead to processing, thereby potentially mitigating the neurotoxic effects associated with amyloid accumulation. anti-X11γ antibody (D-3) is an essential tool for researchers investigating the molecular mechanisms underlying Alzheimer′s disease and the role of β-APP in neuronal function.

The preferred X11γ antibody is X11γ Antibody (B-6): sc-390819.