X11γ Antibody (B-6): sc-390819
- X11γ Antibody (B-6) is a mouse monoclonal IgG2a κ X11γ antibody provided at 200 µg/ml
- raised against amino acids 1-206 mapping at the N-terminus of X11γ of human origin
- X11 gamma Antibody (B-6) is recommended for detection of X11γ of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-X11 gamma Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for X11γ Antibody (B-6) for WB applications. This reagent is now offered in a bundle with X11γ Antibody (B-6) (see ordering information below).
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X11γ Antibody (B-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects X11 gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11γ (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. X11 gamma protein plays a crucial role in regulating β-Amyloid precursor protein (β-APP), a significant component of amyloid plaques found in Alzheimer′s disease patients. By binding to β-APP through its phosphotyrosine binding (PTB) domain, X11γ reduces cellular β-APP secretion and modulates processing pathways, thereby influencing β-APP internalization via the YENPTY motif. This interaction helps mitigate amyloid-beta peptide accumulation, which is implicated in neurodegeneration. Multiple splice variants of X11 have been identified, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), each contributing to β-APP regulation and associated pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
X11γ Antibody (B-6) References:
- The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. | Borg, JP., et al. 1996. Mol Cell Biol. 16: 6229-41. PMID: 8887653
- Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. | Zhang, Z., et al. 1997. EMBO J. 16: 6141-50. PMID: 9321393
- Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. | Okamoto, M. and Südhof, TC. 1997. J Biol Chem. 272: 31459-64. PMID: 9395480
- The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. | Borg, JP., et al. 1998. J Biol Chem. 273: 14761-6. PMID: 9614075
- X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. | Sastre, M., et al. 1998. J Biol Chem. 273: 22351-7. PMID: 9712855
- Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. | Russo, T., et al. 1998. FEBS Lett. 434: 1-7. PMID: 9738440
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11γ Antibody (B-6) | sc-390819 | 200 µg/ml | $316.00 | |||
X11γ Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-526196 | 200 µg Ab; 10 µg BP | $354.00 | |||
X11γ Antibody (B-6) AC | sc-390819 AC | 500 µg/ml, 25% agarose | $416.00 | |||
X11γ Antibody (B-6) HRP | sc-390819 HRP | 200 µg/ml | $316.00 | |||
X11γ Antibody (B-6) FITC | sc-390819 FITC | 200 µg/ml | $330.00 | |||
X11γ Antibody (B-6) PE | sc-390819 PE | 200 µg/ml | $343.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 488 | sc-390819 AF488 | 200 µg/ml | $357.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 546 | sc-390819 AF546 | 200 µg/ml | $357.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 594 | sc-390819 AF594 | 200 µg/ml | $357.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 647 | sc-390819 AF647 | 200 µg/ml | $357.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 680 | sc-390819 AF680 | 200 µg/ml | $357.00 | |||
X11γ Antibody (B-6) Alexa Fluor® 790 | sc-390819 AF790 | 200 µg/ml | $357.00 |