X11γ Inhibitors
Chemical inhibitors of X11γ function primarily by targeting the kinase activity of Glycogen synthase kinase 3 beta (GSK-3β), which is a primary enzyme involved in the phosphorylation of this protein. Lithium Chloride acts as an inhibitor of GSK-3β, leading to a reduction in the phosphorylation of X11γ. Similarly, SB216763 serves as a potent inhibitor, selectively binding to GSK-3 and reducing its ability to phosphorylate X11γ. Indirubin-3'-monoxime, another GSK-3β inhibitor, impedes the enzyme's action, which results in decreased phosphorylation levels of X11γ. CHIR99021 is highly selective for GSK-3 and by inhibiting this kinase, it consequently prevents the phosphorylation of X11γ. AR-A014418 also selectively inhibits GSK-3β, which can lead to reduced phosphorylation of X11γ and thus its inhibition.
In addition to these inhibitors, TDZD-8, a non-ATP competitive inhibitor, obstructs GSK-3β activity, which prevents the phosphorylation of X11γ. H-89, although primarily a protein kinase A inhibitor, exhibits inhibitory effects on GSK-3β, which may result in the reduced phosphorylation of X11γ. BIO, as a GSK-3 specific inhibitor, leads to a decrease in the phosphorylation and activity of X11γ. Similar inhibitory effects are seen with Alsterpaullone and Kenpaullone, both of which inhibit GSK-3β and consequently reduce the phosphorylation state of X11γ. Lastly, Tideglusib and AZD1080, both irreversible inhibitors of GSK-3β, lead to the inhibition of its kinase activity, ultimately preventing the phosphorylation and functional activity of X11γ. Each chemical, by impeding the activity of GSK-3β, ensures that X11γ remains in a less phosphorylated and thereby less active state.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit Glycogen synthase kinase 3 beta (GSK-3β), which is involved in phosphorylation of X11γ. Phosphorylation can regulate protein interactions and function, thus inhibition of GSK-3β by Lithium Chloride can lead to a reduction in X11γ phosphorylation, thereby functionally inhibiting X11γ. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a potent and selective inhibitor of GSK-3, a kinase known to phosphorylate various proteins including X11γ. By inhibiting GSK-3 activity, SB216763 can reduce phosphorylation levels of X11γ, thereby inhibiting its function. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
Indirubin-3'-monoxime is a known inhibitor of GSK-3β. By blocking GSK-3β activity, this chemical can decrease the phosphorylation of X11γ and hence inhibit its function. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR99021 is a highly selective GSK-3 inhibitor. It can inhibit the phosphorylation of X11γ by inhibiting GSK-3, leading to functional inhibition of X11γ. | ||||||
GSK-3β Inhibitor VIII | 487021-52-3 | sc-202636 sc-202636A | 5 mg 10 mg | $134.00 $150.00 | 5 | |
AR-A014418 is a selective GSK-3β inhibitor. It inhibits the kinase activity of GSK-3β, potentially decreasing the phosphorylation and therefore the activity of X11γ. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
BIO is a specific inhibitor of GSK-3. As GSK-3 is involved in the phosphorylation of X11γ, inhibition of GSK-3 by BIO can lead to functional inhibition of X11γ. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that also inhibits GSK-3β. By inhibiting GSK-3β, Alsterpaullone can decrease the phosphorylation state of X11γ, leading to its functional inhibition. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
Kenpaullone is another GSK-3β inhibitor which can inhibit the phosphorylation of downstream proteins such as X11γ, leading to their functional inhibition. | ||||||
Tideglusib | 865854-05-3 | sc-507358 | 10 mg | $77.00 | ||
Tideglusib irreversibly inhibits GSK-3β, which is necessary for the phosphorylation of X11γ. The inhibition of GSK-3β by Tideglusib can functionally inhibit X11γ. | ||||||
AZD1080 | 612487-72-6 | sc-503187 | 2.5 mg | $280.00 | ||
AZD1080 is a GSK-3 inhibitor. By targeting GSK-3, it can inhibit the kinase activity that is responsible for the phosphorylation of X11γ, thereby leading to a functional inhibition of X11γ. | ||||||