von Willebrand Factor/VWF Antibody (F8/44/20): sc-53465

VWF Antibody (F8/44/20) is a mouse monoclonal IgG1 kappa light chain antibody developed to target von Willebrand factor (VWF), a vital multimeric glycoprotein essential for normal blood coagulation. VWF is predominantly located within endothelial cells, where synthesis and storage occur in specialized organelles called Weibel-Palade bodies, as well as in platelets within alpha granules. This strategic localization enables rapid VWF release in response to vascular injury, mediating platelet adhesion and aggregation at damage sites to initiate stable blood clot formation. VWF circulates in plasma, functioning as a carrier for Factor VIII, a key cofactor in the coagulation cascade, ensuring stability and availability during clotting. The precise cellular localization of VWF within endothelial cells and platelets maintains hemostatic balance and prevents excessive bleeding. Anti-VWF antibody (F8/44/20) is raised against VWF isolated from human plasma and is recommended for immunofluorescence (IF) applications with human samples. VWF monoclonal antibody (F8/44/20) facilitates detailed studies on distribution, regulation, and function of VWF within endothelial cells and platelets, contributing to understanding coagulation and von Willebrand disease pathophysiology. Anti-VWF antibody (F8/44/20) advances vascular biology, blood coagulation research, and development of therapeutic strategies for bleeding disorders.

The preferred von Willebrand Factor/VWF antibody is von Willebrand Factor/VWF Antibody (F8/86): sc-53466.