von Willebrand Factor/VWF Antibody (C-12): sc-365712
- von Willebrand Factor/VWF Antibody (C-12) is a mouse monoclonal IgG1 κ, cited in 64 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2779-2813 near the C-terminus of VWF of human origin
- Anti-von Willebrand Factor/VWF Antibody (C-12) is recommended for detection of VWF of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-von Willebrand Factor/VWF Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for von Willebrand Factor/VWF Antibody (C-12) for WB applications. These reagents are now offered in bundles with von Willebrand Factor/VWF Antibody (C-12) (see ordering information below).
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SEE ALSO...
VWF Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the von Willebrand factor (VWF) protein of human origin, specifically recognizing an epitope mapped between amino acids 2779-2813 near the C-terminus of VWF. VWF monoclonal antibody (C-12) is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), and demonstrates reactivity with VWF from mouse, rat, and human species. VWF is a vital multimeric glycoprotein essential for hemostasis, synthesized primarily in endothelial cells and stored in Weibel-Palade bodies, as well as in platelets where VWF resides in alpha granules. Upon vascular injury, VWF is rapidly secreted into the plasma, where VWF plays a critical role in blood coagulation by mediating platelet adhesion and aggregation through interaction with glycoprotein Ib (GPIb) receptors on platelets and binding to exposed collagen in the subendothelial matrix. This interaction initiates the formation of a stable blood clot, preventing excessive bleeding. Additionally, VWF serves as a carrier protein for Factor VIII, a crucial cofactor in the coagulation cascade, protecting Factor VIII from proteolytic degradation and ensuring availability during the clotting process. The functionality of VWF is essential for maintaining hemostatic balance, and any defects or deficiencies in VWF can lead to von Willebrand disease, the most common inherited bleeding disorder characterized by impaired blood clotting and excessive bleeding. By specifically targeting the C-terminal region of VWF, anti-VWF antibody (C-12) enables detailed studies of VWF′s interactions with key coagulation factors and cellular receptors, facilitating a deeper understanding of the molecular mechanisms underlying blood coagulation and the pathophysiology of bleeding disorders. Whether used in basic research to explore VWF′s role in vascular biology or in clinical diagnostics to assess VWF levels and functionality in patient samples, VWF (C-12) antibody provides reliable and precise detection, supporting advancements in the study and management of hemostatic processes and coagulation-related conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
von Willebrand Factor/VWF Antibody (C-12) | sc-365712 | 200 µg/ml | $316.00 | |||
von Willebrand Factor/VWF Antibody (C-12): m-IgG Fc BP-HRP Bundle | sc-529445 | 200 µg Ab; 10 µg BP | $354.00 | |||
von Willebrand Factor/VWF Antibody (C-12): m-IgGκ BP-HRP Bundle | sc-522338 | 200 µg Ab, 40 µg BP | $354.00 | |||
von Willebrand Factor/VWF Antibody (C-12) AC | sc-365712 AC | 500 µg/ml, 25% agarose | $416.00 | |||
von Willebrand Factor/VWF Antibody (C-12) HRP | sc-365712 HRP | 200 µg/ml | $316.00 | |||
von Willebrand Factor/VWF Antibody (C-12) FITC | sc-365712 FITC | 200 µg/ml | $330.00 | |||
von Willebrand Factor/VWF Antibody (C-12) PE | sc-365712 PE | 200 µg/ml | $343.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 488 | sc-365712 AF488 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 546 | sc-365712 AF546 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 594 | sc-365712 AF594 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 647 | sc-365712 AF647 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 680 | sc-365712 AF680 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF Antibody (C-12) Alexa Fluor® 790 | sc-365712 AF790 | 200 µg/ml | $357.00 | |||
von Willebrand Factor/VWF (C-12) Neutralizing Peptide | sc-365712 P | 100 µg/0.5 ml | $68.00 |