VIP Antibody (H-6): sc-25347

VIP Antibody (H-6) is a mouse monoclonal IgG2b kappa light chain antibody engineered to detect the human vasoactive intestinal peptide (VIP), also known as PHM27 or glucagon family member. VIP monoclonal antibody (H-6) is raised against amino acids 1-95 of the VIP protein, ensuring precise binding and high affinity across various experimental techniques including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Vasoactive intestinal peptide plays a pivotal role in smooth muscle relaxation and vasodilation, thereby regulating blood pressure and facilitating intestinal water and electrolyte secretion, which underscores its importance in cardiovascular and gastrointestinal research. Beyond its vasodilatory effects, VIP is integral to neuroprotection, immune system modulation, and exhibits anti-inflammatory properties, making VIP (H-6) antibody a key tool in diverse physiological processes and potential therapeutic applications. VIP monoclonal antibody (H-6) is available in both non-conjugated and multiple conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® dyes, providing flexibility for a wide range of experimental setups. Anti-VIP antibody (H-6) enables scientists to effectively study the mechanisms involving VIP and identify potential therapeutic targets for conditions related to vasodilation, immune regulation, and inflammatory responses.

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VIP Antibody (H-6) References:

1. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.  |  Rouillé, Y., et al. 1995. J Biol Chem. 270: 26488-96. PMID: 7592866
2. Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.  |  Moens, K., et al. 1996. Diabetes. 45: 257-61. PMID: 8549871
3. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.  |  Scrocchi, LA., et al. 1996. Nat Med. 2: 1254-8. PMID: 8898756
4. Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells.  |  Jiang, S., et al. 1997. Cancer Res. 57: 1475-80. PMID: 9108448
5. Specific features of glycogen metabolism in the liver.  |  Bollen, M., et al. 1998. Biochem J. 336 (Pt 1): 19-31. PMID: 9806880
6. Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormone secretion from porcine somatotropes.  |  Martínez-Fuentes, AJ., et al. 1998. Endocrinology. 139: 5116-24. PMID: 9832451

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VIP Antibody (H-6) has 38 citations in a variety of scientific publications.

Primary antibodies like Anti-VIP Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VIP Antibody (H-6) Specifications

Alternate Product Name: vasoactive intestinal peptide

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-95

Epitope Target: VIP

Epitope Species: human

Product Reactivity/Detection: VIP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 38 citations in various scientific publications

Available Conjugates/Forms for VIP Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PACAP antibody is PACAP Antibody (F-2): sc-166180.