PACAP Antibody (F-2): sc-166180

PACAP Antibody (F-2) is a mouse monoclonal IgM kappa light chain antibody designed to detect the human pituitary adenylate cyclase-activating polypeptide (PACAP), also known as ADCYAP1 or adenylate cyclase activating polypeptide 1. PACAP monoclonal antibody (F-2) is raised against amino acids 101-176 of the human PACAP protein, ensuring precise binding and high affinity for use in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PACAP is predominantly located in the cytoplasm of neurons, where PACAP plays a crucial role in neuroprotection, neurodevelopment, and the modulation of neurotransmitter release, highlighting PACAP′s significance in both central and peripheral nervous systems. Additionally, PACAP is involved in the regulation of stress responses, influencing the synthesis of hormones such as growth hormone, and has been implicated in immune system modulation and anti-inflammatory processes. PACAP (F-2) antibody exhibits broad species reactivity, effectively recognizing PACAP from mouse, rat, and human origins, making PACAP (F-2) antibody a versatile tool for comparative studies across different models. Understanding the cellular localization of PACAP is essential for elucidating PACAP′s mechanisms of action and involvement in various physiological and pathological processes, including neurodegenerative diseases and metabolic disorders. Anti-PACAP antibody (F-2) is available in non-conjugated form, providing flexibility for researchers to utilize in multiple experimental setups without interference from labels or tags.

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PACAP Antibody (F-2) References:

1. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.  |  Rouillé, Y., et al. 1995. J Biol Chem. 270: 26488-96. PMID: 7592866
2. Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.  |  Moens, K., et al. 1996. Diabetes. 45: 257-61. PMID: 8549871
3. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.  |  Scrocchi, LA., et al. 1996. Nat Med. 2: 1254-8. PMID: 8898756
4. Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells.  |  Jiang, S., et al. 1997. Cancer Res. 57: 1475-80. PMID: 9108448
5. Specific features of glycogen metabolism in the liver.  |  Bollen, M., et al. 1998. Biochem J. 336 (Pt 1): 19-31. PMID: 9806880
6. Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormone secretion from porcine somatotropes.  |  Martínez-Fuentes, AJ., et al. 1998. Endocrinology. 139: 5116-24. PMID: 9832451

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PACAP Antibody (F-2) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-PACAP Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PACAP Antibody (F-2) Specifications

Alternate Product Name: Pituitary adenylate cyclase-activating polypeptide (PACAP)

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 101-176

Epitope Target: PACAP

Epitope Species: human

Product Reactivity/Detection: PACAP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for PACAP Antibody (F-2): N/A

The preferred VIP antibody is VIP Antibody (H-6): sc-25347.