VDAC1/Porin Antibody (B-6): sc-390996

VDAC1 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects VDAC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-VDAC1 antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The voltage-dependent anion channel 1 (VDAC1) plays a crucial role in regulating mitochondrial metabolism and apoptosis, serving as a gateway for transporting ions and metabolites across the mitochondrial outer membrane. VDAC1′s ability to form channels that allow passage of small molecules is vital for maintaining cellular energy homeostasis and facilitating release of pro-apoptotic factors, such as cytochrome c, during early stages of programmed cell death. VDAC1 interacts with various proteins, including adenine nucleotide translocator (ANT) and pro-apoptotic proteins like Bax, which can influence function and stability. Understanding these interactions and regulatory mechanisms involving VDAC1 is essential for elucidating mitochondrial function and apoptotic process, making VDAC1 (B-6) monoclonal antibody a valuable tool for researchers studying these critical cellular pathways.

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VDAC1/Porin Antibody (B-6) References:

1. DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.  |  Cozens, AL., et al. 1989. J Mol Biol. 206: 261-80. PMID: 2541251
2. A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed.  |  Li, K., et al. 1989. J Biol Chem. 264: 13998-4004. PMID: 2547778
3. VDAC1, mitochondrial dysfunction, and Alzheimer's disease.  |  Shoshan-Barmatz, V., et al. 2018. Pharmacol Res. 131: 87-101. PMID: 29551631
4. VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases.  |  Shoshan-Barmatz, V., et al. 2020. Biomolecules. 10: PMID: 33114780
5. IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling.  |  Yuan, M., et al. 2022. Redox Biol. 52: 102289. PMID: 35344886
6. Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer's disease protects against mitochondrial dysfunction and mitigates brain pathology.  |  Verma, A., et al. 2022. Transl Neurodegener. 11: 58. PMID: 36578022
7. Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.  |  Liu, Y., et al. 2023. Autophagy. 19: 2443-2463. PMID: 36803235
8. HNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer.  |  Zhou, Q., et al. 2023. Cell Death Dis. 14: 356. PMID: 37296105
9. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.  |  Blachly-Dyson, E., et al. 1993. J Biol Chem. 268: 1835-41. PMID: 8420959
10. Mitochondrial control of nuclear apoptosis.  |  Zamzami, N., et al. 1996. J Exp Med. 183: 1533-44. PMID: 8666911
11. Mitochondria and apoptosis.  |  Green, DR. and Reed, JC. 1998. Science. 281: 1309-12. PMID: 9721092
12. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.  |  Marzo, I., et al. 1998. Science. 281: 2027-31. PMID: 9748162

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VDAC1/Porin Antibody (B-6) has 216 citations in a variety of scientific publications.

Primary antibodies like Anti-VDAC1/Porin Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VDAC1/Porin Antibody (B-6) Specifications

Alternate Product Name: VDAC1

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 118-157

Epitope Target: VDAC1

Epitope Species: human

Product Reactivity/Detection: VDAC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 216 citations in various scientific publications

Available Conjugates/Forms for VDAC1/Porin Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin