VCP Antibody (F-5): sc-133211
- VCP Antibody (F-5) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 687-806 mapping at the C-terminus of VCP of human origin
- recommended for detection of VCP of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VCP Antibody (F-5) for WB applications. These reagents are now offered in bundles with VCP Antibody (F-5) (see ordering information below).
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VCP Antibody (F-5) is a mouse monoclonal IgG2b light chain antibody that detects valosin containing protein (VCP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VCP is a crucial member of the AAA family of ATPases, playing a significant role in various cellular processes, including the regulation of the cell cycle and membrane functions. Notably, VCP is involved in the degradation of ubiquitinated proteins, which is essential for maintaining cellular homeostasis and responding to stress. VCP interacts with key proteins such as IκB-α and the 26S proteasome, highlighting VCP′s importance in the proteasome-mediated degradation pathway. This interaction is vital for the regulation of nuclear factor kappa B (NF-κB) signaling, which is critical for immune response and inflammation. VCP′s ability to facilitate the removal of damaged or misfolded proteins underscores VCP′s importance in cellular quality control mechanisms, making anti-VCP antibody (F-5) an invaluable tool for researchers studying cellular stress responses and related diseases.
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VCP Antibody (F-5) References:
- Valosin containing protein associated fronto-temporal lobar degeneration: clinical presentation, pathologic features and pathogenesis. | Weihl, CC. 2011. Curr Alzheimer Res. 8: 252-60. PMID: 21222596
- Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice. | Fusser, M., et al. 2015. PLoS One. 10: e0141472. PMID: 26544960
- Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus. | Phongphaew, W., et al. 2017. Virus Res. 228: 114-123. PMID: 27914931
- Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors. | Bastola, P., et al. 2019. Sci Rep. 9: 11002. PMID: 31358864
- The AAA + ATPase valosin-containing protein (VCP)/p97/Cdc48 interaction network in Leishmania. | Aguiar, BG., et al. 2020. Sci Rep. 10: 13135. PMID: 32753747
- Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth. | Wang, J., et al. 2021. Cancer Res. 81: 4041-4053. PMID: 34099490
- Pathogenic variants of Valosin-containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells. | Ferrari, V., et al. 2022. Neuropathol Appl Neurobiol. 48: e12818. PMID: 35501124
- Valosin-containing-protein pathogenic variant p.R487H in Parkinson's disease. | Piat, C., et al. 2024. Clin Park Relat Disord. 10: 100236. PMID: 38283104
- VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy. | Wang, Z., et al. 2024. Autophagy. 20: 2041-2054. PMID: 38762759
- Dual role of valosin-containing protein (VCP/p97) in mouse sperm during capacitation. | Jabloñski, M., et al. 2024. Reproduction. 168: PMID: 38912971
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VCP Antibody (F-5) | sc-133211 | 200 µg/ml | $322.00 | |||
VCP Antibody (F-5): m-IgGκ BP-HRP Bundle | sc-534600 | 200 µg Ab; 40 µg BP | $361.00 | |||
VCP Antibody (F-5): m-IgG2b BP-HRP Bundle | sc-549269 | 200 µg Ab; 10 µg BP | $361.00 |