VCP Antibody (E-4): sc-133125
- VCP Antibody (E-4) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 687-806 mapping at the C-terminus of VCP of human origin
- recommended for detection of VCP of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VCP Antibody (E-4) for WB applications. These reagents are now offered in bundles with VCP Antibody (E-4) (see ordering information below).
QUICK LINKS
SEE ALSO...
VCP Antibody (E-4) is a mouse monoclonal IgG1 antibody that detects valosin containing protein (VCP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VCP is a crucial member of the AAA family of ATPases, playing a significant role in various cellular processes, including the regulation of the cell cycle and membrane functions. Notably, VCP is involved in the degradation of proteins through interaction with the 26S proteasome, which is essential for maintaining cellular homeostasis. VCP associates with ubiquitinated IκB-α, highlighting its importance in the proteasome-mediated degradation pathway that regulates nuclear factor kappa B (NF-κB) signaling. Proper functioning of VCP is vital, as dysregulation can lead to various diseases, including neurodegenerative disorders and cancer. Anti-VCP antibody (E-4) provides a reliable tool for researchers aiming to study the intricate roles of VCP in cellular mechanisms and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VCP Antibody (E-4) References:
- Implications of Valosin-containing Protein in Promoting Autophagy to Prevent Tau Aggregation. | Chinnathambi, S. and Gorantla, NV. 2021. Neuroscience. 476: 125-134. PMID: 34509548
- WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP. | Lu, G., et al. 2022. Autophagy. 18: 2865-2879. PMID: 35389758
- Valosin-containing protein (VCP/p97) is responsible for the endocytotic trafficking of classical swine fever virus. | Sun, RC., et al. 2022. Vet Microbiol. 272: 109511. PMID: 35849988
- Genotype-phenotype correlations in valosin-containing protein disease: a retrospective muticentre study. | Schiava, M., et al. 2022. J Neurol Neurosurg Psychiatry.. PMID: 35896379
- PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. | Bai, Y., et al. 2023. Autophagy. 19: 1562-1581. PMID: 36300783
- The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. | Saha, I., et al. 2023. Nat Commun. 14: 560. PMID: 36732333
- The immunoexpression of valosin-containing protein and small VCP-interacting protein in rat ovaries. | Kartal, B., et al. 2023. Anat Histol Embryol. 52: 546-551. PMID: 36843060
- Clinical Classification of Variants in the Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy. | Schiava, M., et al. 2023. Neurol Genet. 9: e200093. PMID: 37588275
- Valosin-containing protein acts as a target and mediator of S-nitrosylation in the heart through distinct mechanisms. | Shi, X., et al. 2024. Redox Biol. 72: 103166. PMID: 38685170
- Valosin-containing protein: A potential therapeutic target for cardiovascular diseases. | Rakhe, N. and Bhatt, LK. 2024. Ageing Res Rev. 101: 102511. PMID: 39313037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VCP Antibody (E-4) | sc-133125 | 200 µg/ml | $322.00 | |||
VCP Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-537344 | 200 µg Ab; 10 µg BP | $361.00 | |||
VCP Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-534587 | 200 µg Ab; 40 µg BP | $361.00 | |||
VCP Antibody (E-4): m-IgG1 BP-HRP Bundle | sc-545146 | 200 µg Ab; 20 µg BP | $361.00 |