VAT1 Antibody (E-7): sc-515705
- VAT1 Antibody (E-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 234-250 within an internal region of VAT1 of human origin
- Anti-VAT1 Antibody (E-7) is recommended for detection of VAT1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-VAT1 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-515705 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VAT1 Antibody (E-7) for WB applications. These reagents are now offered in bundles with VAT1 Antibody (E-7) (see ordering information below).
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VAT1 Antibody (E-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects VAT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VAT1 (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. VAT1, or vesicle amine transport protein 1, is a 393 amino acid integral membrane protein predominantly located within cholinergic synaptic vesicles, which are crucial for the storage and release of neurotransmitters at nerve terminals. VAT1 (E-7) monoclonal antibody helps researchers study how VAT1 regulates amine transport into synaptic vesicles, influencing synaptic transmission and communication between neurons. Research using anti-VAT1 antibody (E-7) has revealed that disruptions in VAT1 function can lead to significant consequences, including potential links to endocrine disorders and tumorigenesis, highlighting VAT1′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VAT1 Antibody (E-7) References:
- Synaptic vesicles are constitutively active fusion machines that function independently of Ca2+. | Holt, M., et al. 2008. Curr Biol. 18: 715-722. PMID: 18485705
- VAT-1: an abundant membrane protein from Torpedo cholinergic synaptic vesicles. | Linial, M., et al. 1989. Neuron. 2: 1265-73. PMID: 2483112
- A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. | Miki, Y., et al. 1994. Science. 266: 66-71. PMID: 7545954
- Chromosomal localization of the human vesicular amine transporter genes. | Peter, D., et al. 1993. Genomics. 18: 720-3. PMID: 7905859
- The search for BRCA1. | Friedman, LS., et al. 1994. Cancer Res. 54: 6374-82. PMID: 7987831
- Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. | Smith, TM., et al. 1996. Genome Res. 6: 1029-49. PMID: 8938427
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VAT1 Antibody (E-7) | sc-515705 | 200 µg/ml | $316.00 | |||
VAT1 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-525170 | 200 µg Ab, 40 µg BP | $354.00 | |||
VAT1 Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-549216 | 200 µg Ab; 10 µg BP | $354.00 | |||
VAT1 Antibody (E-7) X | sc-515705 X | 200 µg/0.1 ml | $316.00 | |||
VAT1 Antibody (E-7) AC | sc-515705 AC | 500 µg/ml, 25% agarose | $416.00 | |||
VAT1 Antibody (E-7) HRP | sc-515705 HRP | 200 µg/ml | $316.00 | |||
VAT1 Antibody (E-7) FITC | sc-515705 FITC | 200 µg/ml | $330.00 | |||
VAT1 Antibody (E-7) PE | sc-515705 PE | 200 µg/ml | $343.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 488 | sc-515705 AF488 | 200 µg/ml | $357.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 546 | sc-515705 AF546 | 200 µg/ml | $357.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 594 | sc-515705 AF594 | 200 µg/ml | $357.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 647 | sc-515705 AF647 | 200 µg/ml | $357.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 680 | sc-515705 AF680 | 200 µg/ml | $357.00 | |||
VAT1 Antibody (E-7) Alexa Fluor® 790 | sc-515705 AF790 | 200 µg/ml | $357.00 |