VAT1 Inhibitors
VAT1 inhibitors represent a class of chemical compounds that specifically target the enzyme VAT1, also known as vesicle amine transport 1. This enzyme is a member of the vesicular amine transporter (VAT) family, which plays a crucial role in the cellular regulation of monoamine neurotransmitters. Monoamines, such as dopamine, serotonin, and norepinephrine, are essential neurotransmitters involved in the transmission of signals within the central nervous system. VAT1, in particular, is responsible for the transport of these monoamines into vesicles within nerve cells, a process critical for their storage and subsequent release during neuronal communication.
VAT1 inhibitors stems from the understanding that modulating the activity of this transporter could have significant implications for various physiological processes. By inhibiting VAT1, these compounds may interfere with the packaging and release of monoamines, thereby influencing neurotransmission. The detailed molecular mechanisms through which VAT1 inhibitors exert their effects involve binding to the enzyme and disrupting its normal function, preventing the proper sequestration of monoamines into vesicles. As a consequence, the availability and dynamics of neurotransmitters in the synaptic cleft may be altered. The exploration of VAT1 inhibitors contributes to a broader understanding of cellular processes related to neurotransmitter regulation, offering potential insights into the intricate mechanisms that govern synaptic communication within the nervous system.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
This compound is a known inhibitor of V-ATPases, which are involved in vesicular transport, a pathway where VAT1 can be implicated. Inhibition of V-ATPases can disrupt the vesicular pH balance, potentially affecting VAT1 function. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Similar to Bafilomycin A1, Concanamycin A is a V-ATPase inhibitor that can disrupt vesicular acidification, which may indirectly affect VAT1 activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that interferes with dynamin, a protein involved in vesicle scission. By inhibiting dynamin, the vesicular trafficking processes involving VAT1 could be altered. | ||||||
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $56.00 $100.00 | 9 | |
A bis-benzylisoquinoline alkaloid that has been found to inhibit Ca2+ channels, potentially affecting neurotransmitter release and indirectly impacting VAT1 activity. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a kinase inhibitor that can affect various signaling pathways, possibly altering vesicular transport and thereby VAT1 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can modulate multiple cellular processes, including those related to vesicular transport, and might influence VAT1 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
This is a phosphoinositide 3-kinase inhibitor that can disrupt vesicular trafficking pathways, potentially altering VAT1-related processes. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits clathrin-mediated endocytosis, a key component of vesicular transport, which VAT1 is potentially involved in. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore that can disrupt intracellular calcium levels, potentially affecting vesicle fusion and VAT1 activity. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
This compound can inhibit thiol proteinases and modify cysteine residues, potentially altering protein-protein interactions involved in vesicle transport, and indirectly affecting VAT1. | ||||||