USP43 Antibody (C-8): sc-398436
- USP43 Antibody (C-8) is a mouse monoclonal IgG1 κ USP43 antibody provided at 200 µg/ml
- raised against amino acids 273-360 mapping within an internal region of USP43 of human origin
- USP43 Antibody (C-8) is recommended for detection of USP43 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-USP43 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for USP43 Antibody (C-8) for WB applications. These reagents are now offered in bundles with USP43 Antibody (C-8) (see ordering information below).
USP43 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects USP43 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). USP43 Antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. USP43, also known as ubiquitin specific peptidase 43, plays a critical role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. Specifically, USP43 is involved in the hydrolysis of ubiquitin from target proteins, thereby preventing their degradation and allowing for proper regulation of various cellular processes, including signal transduction and cell cycle progression. This deubiquitinating enzyme is composed of 1,124 amino acids and belongs to the peptidase C19 family, with its gene located on human chromosome 17p13.1. USP43 is expressed at low levels in tissues such as the lung, aorta, and brain, and exists in three isoforms due to alternative splicing, which may contribute to functional diversity in different cellular contexts. USP43′s ability to modulate the ubiquitin pathway underscores its importance in cellular signaling and potential implications in various diseases, making USP43 a valuable target for research and therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
USP43 Antibody (C-8) References:
- Human and mouse proteases: a comparative genomic approach. | Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
- Deubiquitinating enzymes: their roles in development, differentiation, and disease. | Fischer, JA. 2003. Int Rev Cytol. 229: 43-72. PMID: 14669954
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. | Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Kimura, K., et al. 2006. Genome Res. 16: 55-65. PMID: 16344560
- The ubiquitin proteasome system in neuropathology. | Lehman, NL. 2009. Acta Neuropathol. 118: 329-47. PMID: 19597829
- Dissection of USP catalytic domains reveals five common insertion points. | Ye, Y., et al. 2009. Mol Biosyst. 5: 1797-808. PMID: 19734957
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP43 Antibody (C-8) | sc-398436 | 200 µg/ml | $316.00 | |||
USP43 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-530797 | 200 µg Ab; 10 µg BP | $354.00 | |||
USP43 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-524340 | 200 µg Ab, 40 µg BP | $354.00 | |||
USP43 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-544257 | 200 µg Ab; 20 µg BP | $354.00 | |||
USP43 Antibody (C-8) AC | sc-398436 AC | 500 µg/ml, 25% agarose | $416.00 | |||
USP43 Antibody (C-8) HRP | sc-398436 HRP | 200 µg/ml | $316.00 | |||
USP43 Antibody (C-8) FITC | sc-398436 FITC | 200 µg/ml | $330.00 | |||
USP43 Antibody (C-8) PE | sc-398436 PE | 200 µg/ml | $343.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 488 | sc-398436 AF488 | 200 µg/ml | $357.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 546 | sc-398436 AF546 | 200 µg/ml | $357.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 594 | sc-398436 AF594 | 200 µg/ml | $357.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 647 | sc-398436 AF647 | 200 µg/ml | $357.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 680 | sc-398436 AF680 | 200 µg/ml | $357.00 | |||
USP43 Antibody (C-8) Alexa Fluor® 790 | sc-398436 AF790 | 200 µg/ml | $357.00 |