USP14 Antibody (A-1): sc-393872
- USP14 Antibody (A-1) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 195-494 mapping at the C-terminus of USP14 of human origin
- recommended for detection of USP14 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for USP14 Antibody (A-1) for WB applications. These reagents are now offered in bundles with USP14 Antibody (A-1) (see ordering information below).
USP14 Antibody (A-1) is a mouse monoclonal IgG2a antibody that detects USP14 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). USP14, also known as ubiquitin specific peptidase 14, is a crucial cytoplasmic protein that plays a significant role in the ubiquitin-proteasome system by removing ubiquitin moieties from substrates, thus preventing their degradation. This function is vital for maintaining cellular homeostasis and regulating various intracellular processes, including signal transduction and cell cycle progression. USP14 exists as a homodimer and interacts with several other proteins, including the proteasome, where USP14 modulates the degradation of ubiquitin-tagged proteins. Notably, defects in the USP14 gene can lead to severe developmental issues, such as retarded growth or fetal death in mice, underscoring USP14′s importance in early developmental processes. Additionally, USP14 is subject to alternative splicing, resulting in multiple isoforms that may have distinct regulatory roles within the cell. With USP14′s ability to influence protein stability and function, anti-USP14 antibody (A-1) serves as an essential tool for researchers studying the ubiquitin pathway and its implications in various biological contexts.
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USP14 Antibody (A-1) References:
- USP14 inhibitors as potential anticancer agents. | Lundgren, S. and Odrzywol, E. 2018. Future Med Chem. 10: 1741-1743. PMID: 30109962
- A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma. | Zhao, C., et al. 2023. Cell Death Differ. 30: 1-15. PMID: 35906484
- USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice. | Hou, W., et al. 2023. CNS Neurosci Ther.. PMID: 37269080
- USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1. | Wei, D., et al. 2023. Cell Death Dis. 14: 566. PMID: 37633951
- USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis. | Zhang, Z., et al. 2024. Mol Med. 30: 32. PMID: 38424494
- Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson's disease. | Ding, L., et al. 2024. Cell Mol Life Sci. 81: 232. PMID: 38780644
- Targeting the TRIM14/USP14 Axis Enhances Immunotherapy Efficacy by Inducing Autophagic Degradation of PD-L1. | Liu, D., et al. 2024. Cancer Res. 84: 2806-2819. PMID: 38924473
- Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma. | Xu, MH., et al. 2024. Int J Biol Sci. 20: 3269-3284. PMID: 38993552
- ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages. | Rui, H., et al. 2024. Redox Biol. 76: 103318. PMID: 39178733
- USP14 inhibition enhances Parkin-independent mitophagy in iNeurons. | Bernardo, G., et al. 2024. Pharmacol Res. 210: 107484. PMID: 39486496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP14 Antibody (A-1) | sc-393872 | 200 µg/ml | $322.00 | |||
USP14 Antibody (A-1): m-IgG Fc BP-HRP Bundle | sc-538328 | 200 µg Ab; 10 µg BP | $361.00 | |||
USP14 Antibody (A-1): m-IgGκ BP-HRP Bundle | sc-535914 | 200 µg Ab; 40 µg BP | $361.00 | |||
USP14 Antibody (A-1): m-IgG2a BP-HRP Bundle | sc-548270 | 200 µg Ab; 10 µg BP | $361.00 |