UGGT1 Antibody (H-9): sc-374565
- UGGT1 Antibody (H-9) is a mouse monoclonal IgG1 κ UGGT1 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 705-860 mapping within an internal region of UGGT1 of human origin
- UGGT1 Antibody (H-9) is recommended for detection of UGGT1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-UGGT1 Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UGGT1 Antibody (H-9) for WB and IHC(P) applications. These reagents are now offered in bundles with UGGT1 Antibody (H-9) (see ordering information below).
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UGGT1 Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects UGGT1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). UGGT1 (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1 or HUGT1) is a crucial enzyme belonging to the glycosyltransferase 8 family, playing a vital role in glycosylation pathways essential for protein folding and quality control within the cell. UGGT1 identifies misfolded glycoproteins by reglucosylating single N-glycans near misfolded regions, effectively tagging these proteins for recycling back to the endoplasmic reticulum (ER) for refolding or degradation. This process maintains cellular homeostasis and prevents accumulation of dysfunctional proteins, which can lead to various diseases. UGGT1 is predominantly localized in the endoplasmic reticulum and ER-Golgi intermediate compartment, with significant expression observed in skeletal muscle, pancreas, brain, and kidney tissues, highlighting its importance in both structural and functional roles across different organ systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UGGT1 Antibody (H-9) References:
- Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. | Arnold, SM., et al. 2000. Biochemistry. 39: 2149-63. PMID: 10694380
- Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme. | Tessier, DC., et al. 2000. Glycobiology. 10: 403-12. PMID: 10764828
- Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase. | Taylor, SC., et al. 2003. EMBO Rep. 4: 405-11. PMID: 12671684
- The ER glycoprotein quality control system. | Dejgaard, S., et al. 2004. Curr Issues Mol Biol. 6: 29-42. PMID: 14632257
- The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation. | Taylor, SC., et al. 2004. Nat Struct Mol Biol. 11: 128-34. PMID: 14730348
- Structural approaches to the study of oligosaccharides in glycoprotein quality control. | Ito, Y., et al. 2005. Curr Opin Struct Biol. 15: 481-9. PMID: 16154739
- UDP-glucose:glycoprotein glucosyltransferase associates with endoplasmic reticulum chaperones and its activity is decreased in vivo by the inhalation anesthetic halothane. | Amouzadeh, HR., et al. 1997. Chem Res Toxicol. 10: 59-63. PMID: 9074803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UGGT1 Antibody (H-9) | sc-374565 | 200 µg/ml | $316.00 | |||
UGGT1 Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-529773 | 200 µg Ab; 10 µg BP | $354.00 | |||
UGGT1 Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-522779 | 200 µg Ab, 40 µg BP | $354.00 | |||
UGGT1 Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-543683 | 200 µg Ab; 20 µg BP | $354.00 | |||
UGGT1 Antibody (H-9) AC | sc-374565 AC | 500 µg/ml, 25% agarose | $416.00 | |||
UGGT1 Antibody (H-9) HRP | sc-374565 HRP | 200 µg/ml | $316.00 | |||
UGGT1 Antibody (H-9) FITC | sc-374565 FITC | 200 µg/ml | $330.00 | |||
UGGT1 Antibody (H-9) PE | sc-374565 PE | 200 µg/ml | $343.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 488 | sc-374565 AF488 | 200 µg/ml | $357.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 546 | sc-374565 AF546 | 200 µg/ml | $357.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 594 | sc-374565 AF594 | 200 µg/ml | $357.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 647 | sc-374565 AF647 | 200 µg/ml | $357.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 680 | sc-374565 AF680 | 200 µg/ml | $357.00 | |||
UGGT1 Antibody (H-9) Alexa Fluor® 790 | sc-374565 AF790 | 200 µg/ml | $357.00 |