TWIK-2 Antibody (H-6): sc-376515
- TWIK-2 Antibody (H-6) is a mouse monoclonal IgG1 κ TWIK-2 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 29-61 near the N-terminus of TWIK-2 of human origin
- TWIK-2 Antibody (H-6) is recommended for detection of TWIK-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TWIK-2 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TWIK-2 Antibody (H-6) for WB applications. These reagents are now offered in bundles with TWIK-2 Antibody (H-6) (see ordering information below).
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TWIK-2 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TWIK-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TWIK-2 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TWIK-2 protein, a member of the two-pore domain potassium channel family, plays a crucial role in maintaining the resting membrane potential and regulating cellular excitability, which is vital for proper neuronal function and overall cellular homeostasis. Notably, TWIK-2 is predominantly expressed in the pancreas, placenta, and heart in humans, while in mice, TWIK-2 is primarily found in the liver. The unique expression patterns of TWIK-2 highlight potential involvement in various physiological processes, including cardiac function and metabolic regulation. Additionally, TWIK-2 is sensitive to intracellular acidification, which can influence activity and, consequently, potassium ion homeostasis within cells. This makes TWIK-2 an important target for studies related to ion channel physiology and pathophysiology, particularly in conditions where pH levels fluctuate.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TWIK-2 Antibody (H-6) References:
- TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. | Chavez, RA., et al. 1999. J Biol Chem. 274: 7887-92. PMID: 10075682
- Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. | Pountney, DJ., et al. 1999. FEBS Lett. 450: 191-6. PMID: 10359073
- TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. | Lesage, F., et al. 1996. EMBO J. 15: 1004-11. PMID: 8605869
- Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. | Fink, M., et al. 1996. EMBO J. 15: 6854-62. PMID: 9003761
- The structure, function and distribution of the mouse TWIK-1 K+ channel. | Lesage, F., et al. 1997. FEBS Lett. 402: 28-32. PMID: 9013852
- TASK, a human background K+ channel to sense external pH variations near physiological pH. | Duprat, F., et al. 1997. EMBO J. 16: 5464-71. PMID: 9312005
- TRAAK is a mammalian neuronal mechano-gated K+ channel. | Maingret, F., et al. 1999. J Biol Chem. 274: 1381-7. PMID: 9880510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TWIK-2 Antibody (H-6) | sc-376515 | 200 µg/ml | $322.00 | |||
TWIK-2 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529891 | 200 µg Ab; 10 µg BP | $361.00 | |||
TWIK-2 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-522985 | 200 µg Ab, 40 µg BP | $361.00 | |||
TWIK-2 Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543748 | 200 µg Ab; 20 µg BP | $361.00 | |||
TWIK-2 Antibody (H-6) AC | sc-376515 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TWIK-2 Antibody (H-6) HRP | sc-376515 HRP | 200 µg/ml | $322.00 | |||
TWIK-2 Antibody (H-6) FITC | sc-376515 FITC | 200 µg/ml | $336.00 | |||
TWIK-2 Antibody (H-6) PE | sc-376515 PE | 200 µg/ml | $349.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 488 | sc-376515 AF488 | 200 µg/ml | $364.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 546 | sc-376515 AF546 | 200 µg/ml | $364.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 594 | sc-376515 AF594 | 200 µg/ml | $364.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 647 | sc-376515 AF647 | 200 µg/ml | $364.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 680 | sc-376515 AF680 | 200 µg/ml | $364.00 | |||
TWIK-2 Antibody (H-6) Alexa Fluor® 790 | sc-376515 AF790 | 200 µg/ml | $364.00 | |||
TWIK-2 (H-6) Neutralizing Peptide | sc-376515 P | 100 µg/0.5 ml | $69.00 |