TWIK-2 Activators
TWIK-2, a member of the Two-Pore Domain Potassium (K2P) channel family, plays a crucial role in regulating potassium ion flux across cell membranes. As a background leak potassium channel, TWIK-2 contributes to the resting membrane potential of cells in various tissues and organs. This protein is predominantly expressed in the kidney, where it participates in the control of renal potassium handling and thus, maintenance of electrolyte homeostasis. Additionally, TWIK-2 is found in the central nervous system, where it modulates neuronal excitability and contributes to the regulation of neuronal resting membrane potential. Its involvement in these fundamental physiological processes underscores its significance in cellular and organ function.
Activation of TWIK-2 channels involves intricate mechanisms that regulate their gating properties and ion conductance. Various factors influence the activity of TWIK-2 channels, including changes in membrane potential, intracellular pH, and post-translational modifications. These channels are regulated by numerous signaling pathways and protein-protein interactions that modulate their activity in response to physiological cues. Additionally, TWIK-2 channels can be activated by specific ligands or chemical agents that directly interact with the channel protein, altering its conformation and increasing potassium ion conductance. Furthermore, TWIK-2 channels may undergo activation through phosphorylation events mediated by protein kinases, leading to changes in channel activity and ion flux. Understanding the complex mechanisms underlying TWIK-2 activation is crucial for elucidating its physiological roles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
1-EBIO enhances the activity of calcium-activated potassium channels (KCa channels), a family to which TWIK-2 belongs. Through increasing the calcium sensitivity, it could indirectly increase the activity of TWIK-2 channels by promoting a more permissive state for channel opening. | ||||||
DCEBIO | 60563-36-2 | sc-203561 sc-203561A | 10 mg 50 mg | $107.00 $417.00 | 3 | |
DCEBIO acts similarly to 1-EBIO but with greater potency. It interacts with intermediate conductance calcium-activated potassium channels (IK channels), potentially enhancing the open probability of related channels like TWIK-2 in the presence of calcium. | ||||||
NS309 | 18711-16-5 | sc-253202 | 5 mg | $110.00 | ||
NS309 selectively activates SK and IK channels, which are part of the same family as TWIK-2. By modulating the activity of these channels, it could indirectly affect the activity of TWIK-2 channels by altering cellular excitability and calcium signaling. | ||||||
CyPPA | 73029-73-9 | sc-205281 sc-205281A | 10 mg 50 mg | $145.00 $645.00 | ||
CyPPA is a positive modulator of SK channels. While it is more selective for SK channels, its effects on the modulation of cellular excitability could lead to a secondary enhancement of TWIK-2 activity, especially in cells where TWIK-2 contributes to the overall potassium conductance. | ||||||
Chlorzoxazone | 95-25-0 | sc-211078 | 10 mg | $62.00 | ||
Chlorzoxazone is a KCa channel activator that primarily targets KCa2.x subtypes. It may enhance the activity of TWIK-2 channels by a similar mechanism, facilitating the membrane hyperpolarization and thus indirectly promoting TWIK-2 activity. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin has been shown to activate BK channels and could potentially enhance TWIK-2 activity through a similar mechanism, particularly in scenarios where TWIK-2 activity is modulated by transmembrane potential changes. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid is known to modulate various ion channels, including members of the two-pore-domain potassium channel family to which TWIK-2 belongs. It might enhance TWIK-2 activity by influencing the membrane potential and ionic gradients. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Riluzole modulates glutamatergic signaling and has been reported to enhance the activity of various potassium channels. It could indirectly increase TWIK-2 activity through its effects on neuronal excitability and potassium ion homeostasis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
1-Hydroxypyridine-2-thione zinc salt is known to augment the activity of certain potassium channels. It may indirectly increase TWIK-2 activity by modulating the channels' response to physiological stimuli such as changes in zinc ion concentrations. | ||||||
Bithionol | 97-18-7 | sc-239383 | 25 g | $79.00 | ||
Bithionol has been shown to activate chloride channels, and while it is less studied on potassium channels, its effect on ion homeostasis may indirectly enhance TWIK-2 activity by influencing cellular electrochemical gradients. | ||||||