TTI1 Antibody (H-1): sc-271638

TTI1 Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects TTI1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTI1, also known as SMG10, is a 1,089 amino acid protein that plays a crucial role in the DNA damage response (DDR) by functioning as a regulator and being a key component of the TTT complex, which is essential for stabilizing the protein levels of the phosphatidylinositol 3-kinase (PIKK) family. The TTT complex is vital for cellular resistance to various DNA damage stresses, including ionizing radiation, ultraviolet light, and mitomycin C, thereby ensuring the integrity of the genome. TTI1 is involved in the assembly and stabilization of the mTORC1 and mTORC2 complexes, which are critical for cell growth and metabolism. TTI1 undergoes post-translational modification at serine 459, a modification that may influence function and interactions within the cell. The gene encoding TTI1 is located on human chromosome 20, highlighting significance in cellular processes and potential implications in cancer biology and therapeutic interventions. Anti-TTI1 antibody (H-1) is an invaluable tool for researchers studying the intricate mechanisms of DNA damage response and cellular signaling pathways.

The preferred TTI1 antibody is TTI1 Antibody (B-1): sc-365119.