Anti-TTI1 Antibody (B-1) is a mouse monoclonal IgG2b (kappa light chain) TTI1 antibody provided at 200 µg/ml
raised against amino acids 1-300 mapping at the N-terminus of TTI1 of human origin
Anti-TTI1 Antibody (B-1) is recommended for detection of TTI1 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-TTI1 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TTI1 (B-1): sc-365119.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TTI1 Antibody (B-1) is a high quality monoclonal TTI1 antibody (also designated TTI1 antibody) suitable for the detection of the TTI1 protein of mouse, rat and human origin. TTI1 Antibody (B-1) is available as both the non-conjugated anti-TTI1 antibody form, as well as multiple conjugated forms of anti-TTI1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TTI1 (TELO2-interacting protein 1 homolog), also known as SMG10, is a 1,089 amino acid protein that is widely expressed and belongs to the TTI1 family. TTI1 functions as a regulator of the DNA damage response (DDR) and is a component of the TTT complex, which is necessary for the stabilization of protein levels of the phosphatidylinositol 3-kinase (PIKK) family. The TTT complex is a part of the cellular resistance to DNA damage stresses such as ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). In combination with the TTT complex and HSP90, TTI1 may play a role in the proper folding of newly synthesized PIKKs. TTI1 also is involved in the assembly of mTORC1 and mTORC2 complexes, as well as their stabilization and maintenance. TTI1 is post-tanslationally modified at serine 459 and the gene encoding this protein maps to human chromosome 20.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences