TTI1 Inhibitors
TTI1 Inhibitors represent a class of chemical compounds with a distinct mechanism of action and significant relevance in the field of molecular biology and biochemistry. These inhibitors are characterized by their ability to specifically target the TTI1 protein, also known as Tel2-interacting protein 1. TTI1 is a critical component of the Tel2-TTI1-TTI2 (TTT) complex, which plays a pivotal role in the regulation of cellular processes related to protein homeostasis and DNA damage response.
TTI1 Inhibitors act by binding to the TTI1 protein, disrupting its interactions within the TTT complex. This disruption leads to the destabilization of the TTT complex, ultimately impairing its function. The TTT complex is essential for the proper functioning of various cellular processes, including the activation of the mTOR (mammalian target of rapamycin) signaling pathway, which regulates cell growth and proliferation. Additionally, the TTT complex is involved in the recruitment of the PIKK (phosphatidylinositol 3-kinase-related kinase) family of proteins to sites of DNA damage, thus playing a vital role in DNA repair mechanisms. By inhibiting TTI1, these compounds indirectly interfere with these critical cellular processes, making them valuable tools for studying the molecular mechanisms underlying cell growth, DNA repair, and stress response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that can also influence PIKK signaling, thereby indirectly influencing TTI1-related processes. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
An improved analogue of KU-55933 with greater selectivity for ATM, potentially affecting TTI1's role in DNA damage response. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
An ATR kinase inhibitor, with ATR being another member of the PIKK family, potentially modulating TTI1 activity. | ||||||
AZ20 | 1233339-22-4 | sc-503186 | 5 mg | $255.00 | 1 | |
A selective ATR inhibitor that can indirectly influence TTI1's interactions with ATR and related pathways. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
A potent DNA-PK inhibitor, another PIKK that TTI1 may be involved with, potentially affecting TTI1-mediated processes. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $67.00 $278.00 | 3 | |
A DNA-PK inhibitor that can indirectly alter TTI1's role in DNA repair mechanisms. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
An MRE11 inhibitor that disrupts the MRN complex, which is involved in DNA damage response and could affect TTI1 indirectly. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
A checkpoint kinase 1 (Chk1) inhibitor, which is involved in the DNA damage response pathway connected to TTI1. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
A Chk1 and Chk2 inhibitor that can also modulate the TTI1-related DNA damage response pathway. | ||||||