TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12): sc-25331
- TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-190 of TTF-1 of human origin
- recommended for detection of TTF-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-25331 X, 200 µg/0.1 ml)
- See TTF-1/Thyroid Transcription Factor 1/NKX2-1 (8G7G3/1): sc-53136 for TTF-1/Thyroid Transcription Factor 1/NKX2-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12) for WB applications. These reagents are now offered in bundles with TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12) (see ordering information below).
QUICK LINKS
TTF-1 Antibody (F-12) is a mouse monoclonal IgG1 antibody that detects TTF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTF-1, also known as thyroid transcription factor-1, is a crucial member of the Nkx2 family of homeodomain-containing transcription factors, playing a vital role in regulating the transcriptional activity of thyroid-specific genes. TTF-1 is predominantly located in the epithelial cells of the lung, thyroid, and brain, where TTF-1 is essential for organogenesis and the maintenance of differentiated tissue phenotypes. In the lung, TTF-1 is instrumental in the transcription of surfactant proteins A, B, and C, which are critical for proper lung function and gas exchange. Additionally, in the thyroid, TTF-1 enhances the expression of key thyroid-specific markers, including thyroglobulin, thyroperoxidase, and thyrotropin receptors, thereby influencing thyroid hormone synthesis and regulation. Anti-TTF-1 antibody (F-12) has been shown to interact with other proteins such as SRC-1 and CBP, which are important for modulating transcriptional activity, making TTF-1 (F-12) antibody a valuable tool for researchers studying the molecular mechanisms underlying thyroid and lung development and function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12) | sc-25331 | 200 µg/ml | $322.00 | |||
TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-538915 | 200 µg Ab; 10 µg BP | $361.00 | |||
TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12): m-IgG1 BP-HRP Bundle | sc-541145 | 200 µg Ab; 20 µg BP | $361.00 | |||
TTF-1/Thyroid Transcription Factor 1/NKX2-1 Antibody (F-12) X | sc-25331 X | 200 µg/0.1 ml | $322.00 |