TTF-1 Activators
Common TTF-1 Activators include, but are not limited to L-3,3′,5-Triiodothyronine, free acid CAS 6893-02-3, Dexamethasone CAS 50-02-2, Cholecalciferol CAS 67-97-0, PGE2 CAS 363-24-6 and β-Estradiol CAS 50-28-2.
TTF-1 (Thyroid Transcription Factor-1) activators belong to a class of molecules designed to modulate the activity of TTF-1, a critical transcription factor primarily found in the thyroid, lung, and diencephalon regions of the brain. TTF-1 plays a pivotal role in regulating the expression of genes involved in the development, differentiation, and function of these tissues. It acts by binding to specific DNA sequences within the promoter regions of target genes, thereby activating or repressing their transcription. Activators of TTF-1 are compounds or molecules that enhance the transcriptional activity of this transcription factor, possibly by stabilizing its interaction with DNA or other co-factors. Such activators have garnered significant interest in the field of developmental biology and tissue-specific gene expression regulation.
Understanding TTF-1 activators is crucial for unraveling the intricate mechanisms underlying organogenesis and tissue differentiation, especially in the thyroid and lung. By modulating the activity of TTF-1, researchers can gain insights into how specific genes are switched on or off during crucial developmental stages or in response to various environmental cues. Furthermore, the study of TTF-1 activators shed light on disorders related to thyroid and lung function, where aberrant TTF-1 activity has been implicated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
As an active form of thyroid hormone, T3 plays a critical role in thyroid function and development, potentially influencing TTF-1 expression in thyroid cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Often used in in vitro lung development studies and might influence TTF-1 expression in lung cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Given its role in cellular differentiation and proliferation, Vitamin D might modulate TTF-1 expression, especially in lung cells. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
As a lipid mediator involved in various physiological processes, PGE2 might influence TTF-1 expression, especially in the context of lung inflammation or injury. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Hormonal changes might influence TTF-1 expression, especially in the context of lung cancer. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A specific form of retinoic acid that can influence cellular differentiation, potentially affecting TTF-1 expression. | ||||||