TTC4 Antibody (G-6): sc-377251

TTC4 Antibody (G-6) is a mouse monoclonal IgG2b light chain antibody that detects TTC4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTC4, or tetratricopeptide repeat domain 4, is a 387 amino acid protein that plays a crucial role in mediating protein-protein interactions, particularly through three tetratricopeptide repeat motifs. These motifs facilitate TTC4 binding to various partner proteins, including heat shock proteins HSP 90 and HSP 70, as well as replication protein Cdc6, which is essential for DNA replication and cell cycle progression. TTC4′s ability to translocate from cytoplasm to nucleus during G1 and S phases of cell cycle, especially when paired with MSL-1, underscores TTC4′s importance in cellular regulation and potential implications in cancer progression, particularly in malignant melanoma. The gene encoding TTC4 is located on human chromosome 1, which is significant as chromosome 1 encompasses a substantial portion of the human genome, highlighting TTC4′s evolutionary conservation and functional importance across species. Anti-TTC4 antibody (G-6) is an invaluable tool for researchers investigating TTC4′s roles in various biological processes and disease states.

The preferred TTC4 antibody is TTC4 Antibody (F-8): sc-377329.